Literature DB >> 10511686

Acidocalcisome: A novel Ca2+ storage compartment in trypanosomatids and apicomplexan parasites.

R Docampo1, S N Moreno.   

Abstract

Acidocalcisomes are novel acidic Ca2+ storage organelles found in trypanosomatids and apicomplexan parasites, abundant in the intracellular stages of these parasites, and characterized by their high electron density, and high content of phosphorus, Ca2+, Mg2+, Na+ and Zn2+. A number of energy-utilizing pumps and exchangers have been found in these organelles, which underlines their importance in the homeostasis of different elements, as discussed here by Roberto Docampo and Silvia Moreno.

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Year:  1999        PMID： 10511686     DOI： 10.1016/s0169-4758(99)01531-8

Source DB:  PubMed          Journal:  Parasitol Today        ISSN： 0169-4758


  26 in total

1.  Farnesyl diphosphate synthase is a cytosolic enzyme in Leishmania major promastigotes and its overexpression confers resistance to risedronate.

Authors:  Aurora Ortiz-Gómez; Carmen Jiménez; Antonio M Estévez; Juana Carrero-Lérida; Luis M Ruiz-Pérez; Dolores González-Pacanowska
Journal:  Eukaryot Cell       Date:  2006-07

2.  Accumulation and intracellular distribution of antitrypanosomal diamidine compounds DB75 and DB820 in African trypanosomes.

Authors:  Amanda M Mathis; Jacqueline L Holman; Lisa M Sturk; Mohamed A Ismail; David W Boykin; Richard R Tidwell; James Edwin Hall
Journal:  Antimicrob Agents Chemother       Date:  2006-06       Impact factor: 5.191

3.  Cloning and functional expression of a gene encoding a vacuolar-type proton-translocating pyrophosphatase from Trypanosoma cruzi.

Authors:  J E Hill; D A Scott; S Luo; R Docampo
Journal:  Biochem J       Date:  2000-10-01       Impact factor: 3.857

4.  Ultrastructural and biochemical alterations induced by 22,26-azasterol, a delta(24(25))-sterol methyltransferase inhibitor, on promastigote and amastigote forms of Leishmania amazonensis.

Authors:  Juliany C F Rodrigues; Márcia Attias; Carlos Rodriguez; Julio A Urbina; Wanderley de Souza
Journal:  Antimicrob Agents Chemother       Date:  2002-02       Impact factor: 5.191

5.  A plasma membrane-type Ca(2+)-ATPase co-localizes with a vacuolar H(+)-pyrophosphatase to acidocalcisomes of Toxoplasma gondii.

Authors:  S Luo; M Vieira; J Graves; L Zhong; S N Moreno
Journal:  EMBO J       Date:  2001-01-15       Impact factor: 11.598

6.  Regulated degradation of an endoplasmic reticulum membrane protein in a tubular lysosome in Leishmania mexicana.

Authors:  K A Mullin; B J Foth; S C Ilgoutz; J M Callaghan; J L Zawadzki; G I McFadden; M J McConville
Journal:  Mol Biol Cell       Date:  2001-08       Impact factor: 4.138

7.  The calcium-mobilizing messenger nicotinic acid adenine dinucleotide phosphate participates in sperm activation by mediating the acrosome reaction.

Authors:  Sridhar R Vasudevan; Alexander M Lewis; Jennifer W Chan; Claire L Machin; Debroshi Sinha; Antony Galione; Grant C Churchill
Journal:  J Biol Chem       Date:  2010-04-16       Impact factor: 5.157

8.  Dynamics of polymorphism of acidocalcisomes in Leishmania parasites.

Authors:  Kildare Miranda; Roberto Docampo; Orlando Grillo; Anderson Franzen; Márcia Attias; Anibal Vercesi; Helmut Plattner; Joachim Hentschel; Wanderley de Souza
Journal:  Histochem Cell Biol       Date:  2004-05-12       Impact factor: 4.304

9.  Sitamaquine sensitivity in Leishmania species is not mediated by drug accumulation in acidocalcisomes.

Authors:  Carmen López-Martín; José María Pérez-Victoria; Luis Carvalho; Santiago Castanys; Francisco Gamarro
Journal:  Antimicrob Agents Chemother       Date:  2008-09-15       Impact factor: 5.191

10.  Persistent ER stress induces the spliced leader RNA silencing pathway (SLS), leading to programmed cell death in Trypanosoma brucei.

Authors:  Hanoch Goldshmidt; Devorah Matas; Anat Kabi; Shai Carmi; Ronen Hope; Shulamit Michaeli
Journal:  PLoS Pathog       Date:  2010-01-22       Impact factor: 6.823
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