Literature DB >> 10511466

Prohormone convertase-1 is essential for conversion of chromogranin A to pancreastatin.

V Udupi1, H M Lee, A Kurosky, G H Greeley.   

Abstract

The purpose of this study was to test the hypothesis that the endoprotease, prohormone convertase-1 (PC-1), is involved in the processing of the precursor protein chromogranin A (CGA) to a smaller peptide called pancreastatin (PST). A human pancreatic carcinoid cell line (BON) that expresses PC-1, CGA and PST was stably transfected with antisense PC-1 mRNA. BON cells expressing antisense PC-1 mRNA showed nearly complete abolishment of PC-1 protein (approximately 95% reduction) and an 80% reduction in cell content of PST immunoreactivity (PST-IR) as assessed by high-performance liquid chromatography in combination with measurement of PST-IR. These findings indicate that PC-1 is essential for processing CGA to PST.

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Year:  1999        PMID： 10511466     DOI： 10.1016/s0167-0115(99)00061-0

Source DB:  PubMed          Journal:  Regul Pept        ISSN： 0167-0115


  8 in total

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Journal:  J Mol Med (Berl)       Date:  2006-05-11       Impact factor: 4.599

Review 2.  Chromogranin A as a crucial factor in the sorting of peptide hormones to secretory granules.

Authors:  Salah Elias; Charlène Delestre; Maite Courel; Youssef Anouar; Maite Montero-Hadjadje
Journal:  Cell Mol Neurobiol       Date:  2010-11-03       Impact factor: 5.046

3.  Serum pancreastatin: the long sought universal, sensitive, specific tumor marker for neuroendocrine tumors?

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Journal:  Pancreas       Date:  2012-05       Impact factor: 3.327

4.  Pancreatitis activates pancreatic apelin-APJ axis in mice.

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Journal:  Am J Physiol Gastrointest Liver Physiol       Date:  2013-05-16       Impact factor: 4.052

5.  Chromogranin a processing in human pituitary adenomas and carcinomas: analysis with region-specific antibodies.

Authors:  Long Jin; Shuya Zhang; Jill Bayliss; Bernd Scheithauer; Xiang Qian; Ikuo Kobayashi; Mats Stridsberg; Ricardo V Lloyd
Journal:  Endocr Pathol       Date:  2003       Impact factor: 3.943

6.  Peptidomics of enteroendocrine cells and characterisation of potential effects of a novel preprogastrin derived-peptide on glucose tolerance in lean mice.

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Journal:  Peptides       Date:  2021-03-17       Impact factor: 3.750

Review 7.  Isolation and Proteomics of the Insulin Secretory Granule.

Authors:  Nicholas Norris; Belinda Yau; Melkam Alamerew Kebede
Journal:  Metabolites       Date:  2021-04-30

8.  Chromogranin A and its fragments as regulators of small intestinal neuroendocrine neoplasm proliferation.

Authors:  Francesco Giovinazzo; Simon Schimmack; Bernhard Svejda; Daniele Alaimo; Roswitha Pfragner; Irvin Modlin; Mark Kidd
Journal:  PLoS One       Date:  2013-11-19       Impact factor: 3.240
  8 in total

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