Action of C-type natriuretic peptide (CNP) on passive avoidance learning in rats: involvement of transmitters.

The action of C-type of natriuretic peptide (CNP) was tested on one-way passive avoidance learning in rats. The involvement of transmitters was investigated by pretreating the animals with different receptor blockers. CNP administered into the lateral brain ventricle caused a dose-dependent facilitation of learning and consolidation of passive avoidance learning, but was ineffective on retrieval. Pretreatment of the animals with atropine, haloperidol or the nitric oxide synthase inhibitor nitro-L-arginine abolished the action of CNP. Phenoxybenzamine, naloxone, bicuculline, propranolol and methysergide were ineffective in modifying the action of CNP on consolidation. The results suggest that CNP is able to improve the learning and consolidation of learning in a passive avoidance paradigm, but is ineffective on retrieval processes. In the action of CNP, dopamine, acetylcholine and nitric oxide could be the mediating transmitters.