Literature DB >> 10509920

Combinatorial search of substituted beta-cyclodextrins for phosphatase-like activity.

J Yu1, Y Zhao, M J Holterman, D L Venton.   

Abstract

Thirteen per-6-akylamino-6-deoxy-beta-cyclodextrin libraries (beta-CD libraries) were generated by a solution-phase combinatorial synthesis starting from per-6-iodo-6-deoxy-beta-CD and different combinations of eleven individual amine nucleophiles. Certain libraries showed the ability to hydrolyzep-nitrophenyl phosphate in the presence of Zn2+.

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Year:  1999        PMID: 10509920     DOI: 10.1016/s0960-894x(99)00468-0

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN: 0960-894X            Impact factor:   2.823


  1 in total

1.  Per-6-substituted beta-cyclodextrin libraries inhibit formation of beta-amyloid-peptide (A beta)-derived, soluble oligomers.

Authors:  Jiaxin Yu; Lara Bakhos; Lei Chang; Mark J Holterman; William L Klein; Duane L Venton
Journal:  J Mol Neurosci       Date:  2002 Aug-Oct       Impact factor: 3.444

  1 in total

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