| Literature DB >> 10508723 |
Abstract
The frequency and rates of ascent and dissemination of antibiotic resistance in bacterial populations are anticipated to be directly related to the volume of antibiotic use and inversely related to the cost that resistance imposes on the fitness of bacteria. The data available from recent laboratory studies suggest that most, but not all, resistance-determining mutations and accessory elements engender some fitness cost, but those costs are likely to be ameliorated by subsequent evolution.Entities:
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Year: 1999 PMID： 10508723 DOI： 10.1016/s1369-5274(99)00005-3
Source DB: PubMed Journal: Curr Opin Microbiol ISSN： 1369-5274 Impact factor: 7.934