Literature DB >> 10508710

Recent advances in xenotransplantation.

M S Sandrin1, I F McKenzie.   

Abstract

The major barrier to clinically successful pig-to-human xenotransplantation is antibody- and complement-dependent hyperacute rejection, known to be due to host anti-Galalpha(1,3)Gal antibodies. Strategies aimed at eliminating hyperacute rejection involve transgenic approaches to eliminate or reduce expression of Galalpha(1,3)Gal or to reduce complement activation; some of these are now in clinical trials in primates. Another important role of Galalpha(1,3)Gal that is becoming more evident is in antibody-dependent and -independent xenograft rejection that is mediated by natural killer cells and monocytes.

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Year:  1999        PMID： 10508710     DOI： 10.1016/s0952-7915(99)00011-4

Source DB:  PubMed          Journal:  Curr Opin Immunol        ISSN： 0952-7915            Impact factor:   7.486


  6 in total

Review 1.  Farming for spare body parts: silk purse or sow's ear.

Authors:  J P Atkinson
Journal:  Trans Am Clin Climatol Assoc       Date:  2001

2.  Highly efficient chemoenzymatic synthesis and facile purification of α-Gal pentasaccharyl ceramide Galα3nLc4βCer.

Authors:  Abhishek Santra; Yanhong Li; Hai Yu; Teri J Slack; Peng George Wang; Xi Chen
Journal:  Chem Commun (Camb)       Date:  2017-07-20       Impact factor: 6.222

3.  Study of full-length porcine endogenous retrovirus genomes with envelope gene polymorphism in a specific-pathogen-free Large White swine herd.

Authors:  S Bösch; C Arnauld; A Jestin
Journal:  J Virol       Date:  2000-09       Impact factor: 5.103

4.  Comparison of tracheal reconstruction with allograft, fresh xenograft and artificial trachea scaffold in a rabbit model.

Authors:  Jae Yeon Lee; Jeong Hun Park; Dong-Woo Cho
Journal:  J Artif Organs       Date:  2018-05-12       Impact factor: 1.731

5.  Production of alpha 1,3-galactosyltransferase-deficient pigs.

Authors:  Carol J Phelps; Chihiro Koike; Todd D Vaught; Jeremy Boone; Kevin D Wells; Shu-Hung Chen; Suyapa Ball; Susan M Specht; Irina A Polejaeva; Jeff A Monahan; Pete M Jobst; Sugandha B Sharma; Ashley E Lamborn; Amy S Garst; Marilyn Moore; Anthony J Demetris; William A Rudert; Rita Bottino; Suzanne Bertera; Massimo Trucco; Thomas E Starzl; Yifan Dai; David L Ayares
Journal:  Science       Date:  2002-12-19       Impact factor: 47.728

6.  Humans lack iGb3 due to the absence of functional iGb3-synthase: implications for NKT cell development and transplantation.

Authors:  Dale Christiansen; Julie Milland; Effie Mouhtouris; Hilary Vaughan; Daniel G Pellicci; Malcolm J McConville; Dale I Godfrey; Mauro S Sandrin
Journal:  PLoS Biol       Date:  2008-07-15       Impact factor: 8.029
  6 in total

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