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Literature DB >> 10508699

APC: the plot thickens.

Abstract

Adenomatous polyposis coli (APC) is an important tumour suppressor in the human colon. It is conserved between human and flies, and promotes, together with Axin and glycogen synthase kinase 3 (GSK3), the degradation of the Wnt-signalling effector beta-catenin. Recent experiments have shaped our understanding of how Axin and GSK3 function but the role of APC in this process remains elusive.

Entities: Disease Gene Species

Mesh：

Substances：

Year: 1999 PMID： 10508699 DOI： 10.1016/s0959-437x(99)00016-7

Source DB: PubMed Journal: Curr Opin Genet Dev ISSN： 0959-437X Impact factor: 5.578

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Cited

19 in total

1. Explaining differences in the severity of familial adenomatous polyposis and the search for modifier genes.

Authors: R Houlston; M Crabtree; R Phillips; M Crabtree; I Tomlinson
Journal: Gut Date: 2001-01 Impact factor: 23.059

2. gamma-catenin is regulated by the APC tumor suppressor and its oncogenic activity is distinct from that of beta-catenin.

Authors: F T Kolligs; B Kolligs; K M Hajra; G Hu; M Tani; K R Cho; E R Fearon
Journal: Genes Dev Date: 2000-06-01 Impact factor: 11.361

Review 3. The angiogenic switch molecule, secreted FGF-binding protein, an indicator of early stages of pancreatic and colorectal adenocarcinoma.

Authors: Elena Tassi; Anton Wellstein
Journal: Semin Oncol Date: 2006-12 Impact factor: 4.929

10. Tumor angiogenesis: initiation and targeting - therapeutic targeting of an FGF-binding protein, an angiogenic switch molecule, and indicator of early stages of gastrointestinal adenocarcinomas -.

Authors: Elena Tassi; Anton Wellstein
Journal: Cancer Res Treat Date: 2006-12-31 Impact factor: 4.679

APC: the plot thickens.

1. Explaining differences in the severity of familial adenomatous polyposis and the search for modifier genes.

2. gamma-catenin is regulated by the APC tumor suppressor and its oncogenic activity is distinct from that of beta-catenin.

Review 3. The angiogenic switch molecule, secreted FGF-binding protein, an indicator of early stages of pancreatic and colorectal adenocarcinoma.

4. Seven Wnt homologues in Drosophila: a case study of the developing tracheae.

5. Actin-dependent membrane association of the APC tumour suppressor in polarized mammalian epithelial cells.

6. Capsaicin represses transcriptional activity of β-catenin in human colorectal cancer cells.

7. Oncogenic mutants of RON and MET receptor tyrosine kinases cause activation of the beta-catenin pathway.

8. Inhibition of Wnt signaling by ICAT, a novel beta-catenin-interacting protein.

9. Deregulated beta-catenin induces a p53- and ARF-dependent growth arrest and cooperates with Ras in transformation.

10. Tumor angiogenesis: initiation and targeting - therapeutic targeting of an FGF-binding protein, an angiogenic switch molecule, and indicator of early stages of gastrointestinal adenocarcinomas -.