Literature DB >> 10508650

Integrin alpha(IIb)beta(3) signaling in platelet adhesion and aggregation.

L V Parise1.   

Abstract

Intracellular signals are received and generated by the alpha(IIb)beta(3) integrin on platelets. Recent advances have been made in the areas of agonist receptors that initiate platelet activation, downstream signaling molecules (e.g. small G-proteins and kinases) and changes in ligand-occupied alpha(IIb)beta(3) that cause further signaling and clot retraction.

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Year:  1999        PMID： 10508650     DOI： 10.1016/s0955-0674(99)00018-6

Source DB:  PubMed          Journal:  Curr Opin Cell Biol        ISSN： 0955-0674            Impact factor:   8.382


  14 in total

1.  Green fluorescent protein (GFP) tagged to the cytoplasmic tail of alphaIIb or beta3 allows the expression of a fully functional integrin alphaIIb(beta3): effect of beta3GFP on alphaIIb(beta3) ligand binding.

Authors:  S Plançon; M C Morel-Kopp; E Schaffner-Reckinger; P Chen; N Kieffer
Journal:  Biochem J       Date:  2001-07-15       Impact factor: 3.857

2.  On the activation of integrin αIIbβ3: outside-in and inside-out pathways.

Authors:  Mehrdad Mehrbod; Stephen Trisno; Mohammad R K Mofrad
Journal:  Biophys J       Date:  2013-09-17       Impact factor: 4.033

3.  Disruption of the mouse mu-calpain gene reveals an essential role in platelet function.

Authors:  M Azam; S S Andrabi; K E Sahr; L Kamath; A Kuliopulos; A H Chishti
Journal:  Mol Cell Biol       Date:  2001-03       Impact factor: 4.272

4.  Positional importance of Pro53 adjacent to the Arg49-Gly50-Asp51 sequence of rhodostomin in binding to integrin alphaIIbbeta3.

Authors:  C P Chang; J C Chang; H H Chang; W J Tsai; S J Lo
Journal:  Biochem J       Date:  2001-07-01       Impact factor: 3.857

5.  The unique N-terminus of R-ras is required for Rac activation and precise regulation of cell migration.

Authors:  Stephen P Holly; Mark K Larson; Leslie V Parise
Journal:  Mol Biol Cell       Date:  2005-03-16       Impact factor: 4.138

6.  Sequential activation of p38 and ERK pathways by cGMP-dependent protein kinase leading to activation of the platelet integrin alphaIIb beta3.

Authors:  Zhenyu Li; Guoying Zhang; Robert Feil; Jiahuai Han; Xiaoping Du
Journal:  Blood       Date:  2005-10-06       Impact factor: 22.113

7.  Breast adenocarcinoma cell adhesion to the vascular subendothelium in whole blood and under flow conditions: effects of alphavbeta3 and alphaIIbbeta3 antagonists.

Authors:  Noëlia Gomes; Jany Vassy; Claude Lebos; Brigitte Arbeille; Chantal Legrand; Françoise Fauvel-Lafeve
Journal:  Clin Exp Metastasis       Date:  2004       Impact factor: 5.150

8.  Mechanics of transient platelet adhesion to von Willebrand factor under flow.

Authors:  Nipa A Mody; Oleg Lomakin; Teresa A Doggett; Thomas G Diacovo; Michael R King
Journal:  Biophys J       Date:  2004-11-08       Impact factor: 4.033

9.  A novel form of integrin dysfunction involving beta1, beta2, and beta3 integrins.

Authors:  Alison McDowall; David Inwald; Birgit Leitinger; Alison Jones; Ri Liesner; Nigel Klein; Nancy Hogg
Journal:  J Clin Invest       Date:  2003-01       Impact factor: 14.808

Review 10.  Mechanisms of talin-dependent integrin signaling and crosstalk.

Authors:  Mitali Das; Sujay Ithychanda; Jun Qin; Edward F Plow
Journal:  Biochim Biophys Acta       Date:  2013-07-24
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