Literature DB >> 10508427

A ureido-thioisobutyric acid (GW9578) is a subtype-selective PPARalpha agonist with potent lipid-lowering activity.

P J Brown1, D A Winegar, K D Plunket, L B Moore, M C Lewis, J G Wilson, S S Sundseth, C S Koble, Z Wu, J M Chapman, J M Lehmann, S A Kliewer, T M Willson.   

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Year:  1999        PMID： 10508427     DOI： 10.1021/jm9903601

Source DB:  PubMed          Journal:  J Med Chem        ISSN： 0022-2623            Impact factor:   7.446


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  15 in total

1.  A selective peroxisome proliferator-activated receptor delta agonist promotes reverse cholesterol transport.

Authors:  W R Oliver; J L Shenk; M R Snaith; C S Russell; K D Plunket; N L Bodkin; M C Lewis; D A Winegar; M L Sznaidman; M H Lambert; H E Xu; D D Sternbach; S A Kliewer; B C Hansen; T M Willson
Journal:  Proc Natl Acad Sci U S A       Date:  2001-04-17       Impact factor: 11.205

2.  Synthesis, radiolabeling and initial in vivo evaluation of [(11)C]KSM-01 for imaging PPAR-α receptors.

Authors:  Kiran Kumar Solingapuram Sai; Kun-Eek Kil; Zhude Tu; Wenhua Chu; Brian N Finck; Justin M Rothfuss; Kooresh I Shoghi; Michael J Welch; Robert J Gropler; Robert H Mach
Journal:  Bioorg Med Chem Lett       Date:  2012-08-09       Impact factor: 2.823

3.  Bezafibrate induces acyl-CoA oxidase mRNA levels and fatty acid peroxisomal beta-oxidation in rat white adipose tissue.

Authors:  M Vázquez; N Roglans; A Cabrero; C Rodríguez; T Adzet; M Alegret; R M Sánchez; J C Laguna
Journal:  Mol Cell Biochem       Date:  2001-01       Impact factor: 3.396

4.  Expression and regulation of sterol 27-hydroxylase (CYP27A1) in human macrophages: a role for RXR and PPARgamma ligands.

Authors:  Carmel M Quinn; Wendy Jessup; Jenny Wong; Leonard Kritharides; Andrew J Brown
Journal:  Biochem J       Date:  2005-02-01       Impact factor: 3.857

5.  Cell-specific toxicity of fibrates in human embryonal rhabdomyosarcoma cells.

Authors:  Takayoshi Maiguma; Koji Fujisaki; Yoshinori Itoh; Kazutaka Makino; Daisuke Teshima; Fumi Takahashi-Yanaga; Toshiyuki Sasaguri; Ryozo Oishi
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  2003-02-08       Impact factor: 3.000

6.  Functional analysis of peroxisome-proliferator-responsive element motifs in genes of fatty acid-binding proteins.

Authors:  Christian Schachtrup; Tanja Emmler; Bertram Bleck; Anton Sandqvist; Friedrich Spener
Journal:  Biochem J       Date:  2004-08-15       Impact factor: 3.857

7.  Bezafibrate at clinically relevant doses decreases serum/liver triglycerides via down-regulation of sterol regulatory element-binding protein-1c in mice: a novel peroxisome proliferator-activated receptor alpha-independent mechanism.

Authors:  Takero Nakajima; Naoki Tanaka; Hiroki Kanbe; Atsushi Hara; Yuji Kamijo; Xiaowei Zhang; Frank J Gonzalez; Toshifumi Aoyama
Journal:  Mol Pharmacol       Date:  2009-01-05       Impact factor: 4.436

Review 8.  PPARs and the cardiovascular system.

Authors:  Milton Hamblin; Lin Chang; Yanbo Fan; Jifeng Zhang; Y Eugene Chen
Journal:  Antioxid Redox Signal       Date:  2009-06       Impact factor: 8.401

9.  The Effect of PPAR Agonists on the Migration of Mature and Immature Eosinophils.

Authors:  Steven G Smith; Haruki Imaoka; Neha Punia; Anam Irshad; Luke L Janssen; Roma Sehmi; Gail M Gauvreau
Journal:  PPAR Res       Date:  2012-06-28       Impact factor: 4.964

Review 10.  Therapeutic targets, novel drugs, and delivery systems for diabetes associated NAFLD and liver fibrosis.

Authors:  Virender Kumar; Xiaofei Xin; Jingyi Ma; Chalet Tan; Natalia Osna; Ram I Mahato
Journal:  Adv Drug Deliv Rev       Date:  2021-07-24       Impact factor: 17.873
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