Literature DB >> 10508042

Bactericidal activity and postantibiotic effect of levofloxacin against anaerobes.

S L Pendland1, M Diaz-Linares, K W Garey, J G Woodward, S Ryu, L H Danziger.   

Abstract

The bactericidal activity and postantibiotic effect (PAE) of levofloxacin against nine anaerobes were determined. Levofloxacin at concentrations of the MIC and twice the MIC was bactericidal at 24 h to five of nine and nine of nine strains, respectively. The PAE of levofloxacin following a 2-h exposure ranged from 0.06 to 2.88 h.

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Year:  1999        PMID： 10508042      PMCID： PMC89518          DOI： 10.1128/AAC.43.10.2547

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  14 in total

Review 1.  The mode of action of quinolones: the paradox in activity of low and high concentrations and activity in the anaerobic environment.

Authors:  C S Lewin; I Morrissey; J T Smith
Journal:  Eur J Clin Microbiol Infect Dis       Date:  1991-04       Impact factor: 3.267

Review 2.  Possible role for the new fluoroquinolones (levofloxacin, grepafloxacin, trovafloxacin, clinafloxacin, sparfloxacin, and DU-6859a) in the treatment of anaerobic infections: review of current information on efficacy and safety.

Authors:  E J Goldstein
Journal:  Clin Infect Dis       Date:  1996-12       Impact factor: 9.079

3.  Postantibiotic effect and postantibiotic sub-MIC effect of levofloxacin compared to those of ofloxacin, ciprofloxacin, erythromycin, azithromycin, and clarithromycin against 20 pneumococci.

Authors:  S K Spangler; G Lin; M R Jacobs; P C Appelbaum
Journal:  Antimicrob Agents Chemother       Date:  1998-05       Impact factor: 5.191

4.  Comparison of the postantibiotic and postantibiotic sub-MIC effects of levofloxacin and ciprofloxacin on Staphylococcus aureus and Streptococcus pneumoniae.

Authors:  L Licata; C E Smith; R M Goldschmidt; J F Barrett; M Frosco
Journal:  Antimicrob Agents Chemother       Date:  1997-05       Impact factor: 5.191

5.  Postantibiotic effect of DU-6859a and levofloxacin as compared with ofloxacin.

Authors:  A K Houston; R N Jones
Journal:  Diagn Microbiol Infect Dis       Date:  1994-01       Impact factor: 2.803

6.  The postantibiotic suppressive effect of L-ofloxacin, an optically active isomer of ofloxacin.

Authors:  K P Fu; B Foleno; M E Rosenthale
Journal:  Diagn Microbiol Infect Dis       Date:  1992 May-Jun       Impact factor: 2.803

7.  Bactericidal activity of DU-6859a compared to activities of three quinolones, three beta-lactams, clindamycin, and metronidazole against anaerobes as determined by time-kill methodology.

Authors:  S K Spangler; M R Jacobs; P C Appelbaum
Journal:  Antimicrob Agents Chemother       Date:  1997-04       Impact factor: 5.191

8.  Effect of growth conditions on antimicrobial activity of DU-6859a and its bactericidal activity determined by the killing curve method.

Authors:  M Tanaka; K Hoshino; M Hohmura; H Ishida; A Kitamura; K Sato; I Hayakawa; T Nishino
Journal:  J Antimicrob Chemother       Date:  1996-06       Impact factor: 5.790

9.  Effect of aerobic and anaerobic environments on antistaphylococcal activities of five fluoroquinolones.

Authors:  R A Zabinski; K J Walker; A J Larsson; J A Moody; G W Kaatz; J C Rotschafer
Journal:  Antimicrob Agents Chemother       Date:  1995-02       Impact factor: 5.191

10.  Antimicrobial activity of ciprofloxacin against Pseudomonas aeruginosa, Escherichia coli, and Staphylococcus aureus determined by the killing curve method: antibiotic comparisons and synergistic interactions.

Authors:  L J Chalkley; H J Koornhof
Journal:  Antimicrob Agents Chemother       Date:  1985-08       Impact factor: 5.191
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  3 in total

Review 1.  Levofloxacin: a review of its use in the treatment of bacterial infections in the United States.

Authors:  Katherine F Croom; Karen L Goa
Journal:  Drugs       Date:  2003       Impact factor: 9.546

Review 2.  Levofloxacin: an updated review of its use in the treatment of bacterial infections.

Authors:  Miriam Hurst; Harriet M Lamb; Lesley J Scott; David P Figgitt
Journal:  Drugs       Date:  2002       Impact factor: 9.546

3.  Bactericidal activities of methoxyfluoroquinolones gatifloxacin and moxifloxacin against aerobic and anaerobic respiratory pathogens in serum.

Authors:  Gary E Stein; Sharon Schooley; Kerin L Tyrrell; Diane M Citron; Ellie J C Goldstein
Journal:  Antimicrob Agents Chemother       Date:  2003-04       Impact factor: 5.191
  3 in total

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