Literature DB >> 10508038

Anti-Kaposi's sarcoma and antiangiogenic activities of sulfated dextrins.

M Thornton1, L Barkley, J C Mason, S Shaunak.   

Abstract

Delivery of the sulfated polysaccharide dextrin 2-sulfate by the intraperitoneal route to the lymphatic circulation resulted in a clinically significant improvement in Kaposi's sarcoma in three patients. Our in vitro studies show that although sulfated dextrins do not interfere with the growth of isolated human umbilical vein endothelial cells, they do inhibit the morphological differentiation of endothelial cells into tubes as well as reduce new vessel formation in a placental angiogenesis assay. The antiangiogenic effect of dextrin 6-sulfate is greater than that of dextrin 2-sulfate and is independent of their anti-human immunodeficiency virus type 1 activities.

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Year:  1999        PMID： 10508038      PMCID： PMC89514          DOI： 10.1128/AAC.43.10.2528

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  36 in total

1.  In vitro model of angiogenesis using a human endothelium-derived permanent cell line: contributions of induced gene expression, G-proteins, and integrins.

Authors:  J Bauer; M Margolis; C Schreiner; C J Edgell; J Azizkhan; E Lazarowski; R L Juliano
Journal:  J Cell Physiol       Date:  1992-12       Impact factor: 6.384

2.  Immunohistochemical and electron microscopic profiles of cutaneous Kaposi's sarcoma and bacillary angiomatosis.

Authors:  M Kostianovsky; Y Lamy; M A Greco
Journal:  Ultrastruct Pathol       Date:  1992 Nov-Dec       Impact factor: 1.094

3.  JC70: a new monoclonal antibody that detects vascular endothelium associated antigen on routinely processed tissue sections.

Authors:  D V Parums; J L Cordell; K Micklem; A R Heryet; K C Gatter; D Y Mason
Journal:  J Clin Pathol       Date:  1990-09       Impact factor: 3.411

4.  Inhibition of tumor-induced angiogenesis by sulfated chitin derivatives.

Authors:  J Murata; I Saiki; T Makabe; Y Tsuta; S Tokura; I Azuma
Journal:  Cancer Res       Date:  1991-01-01       Impact factor: 12.701

5.  Inhibition by pentosan polysulfate (PPS) of heparin-binding growth factors released from tumor cells and blockage by PPS of tumor growth in animals.

Authors:  G Zugmaier; M E Lippman; A Wellstein
Journal:  J Natl Cancer Inst       Date:  1992-11-18       Impact factor: 13.506

6.  Response of glioblastoma cell lines to low dose rate irradiation.

Authors:  L A Marin; C E Smith; M Y Langston; D Quashie; L E Dillehay
Journal:  Int J Radiat Oncol Biol Phys       Date:  1991-07       Impact factor: 7.038

7.  Nitric oxide and endothelin secretion by brain microvessel endothelial cells: regulation by cyclic nucleotides.

Authors:  O Durieu-Trautmann; C Fédérici; C Créminon; N Foignant-Chaverot; F Roux; M Claire; A D Strosberg; P O Couraud
Journal:  J Cell Physiol       Date:  1993-04       Impact factor: 6.384

8.  Administration of pentosan polysulfate to patients with human immunodeficiency virus-associated Kaposi's sarcoma.

Authors:  J M Pluda; L E Shay; A Foli; S Tannenbaum; P J Cohen; B R Goldspiel; D Adamo; M R Cooper; S Broder; R Yarchoan
Journal:  J Natl Cancer Inst       Date:  1993-10-06       Impact factor: 13.506

9.  Microtubule disruption stimulates DNA synthesis in bovine endothelial cells and potentiates cellular response to basic fibroblast growth factor.

Authors:  L Liaw; S M Schwartz
Journal:  Am J Pathol       Date:  1993-09       Impact factor: 4.307

10.  Characterization of a spontaneously transformed human endothelial cell line.

Authors:  G W Cockerill; G Meyer; L Noack; M A Vadas; J R Gamble
Journal:  Lab Invest       Date:  1994-10       Impact factor: 5.662
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  1 in total

1.  Accelerated healing of cutaneous leishmaniasis in non-healing BALB/c mice using water soluble amphotericin B-polymethacrylic acid.

Authors:  Karina Corware; Debra Harris; Ian Teo; Matthew Rogers; Kikkeri Naresh; Ingrid Müller; Sunil Shaunak
Journal:  Biomaterials       Date:  2011-07-31       Impact factor: 12.479
  1 in total

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