Literature DB >> 10506556

Precisely localized LTD in the neocortex revealed by infrared-guided laser stimulation.

H Dodt1, M Eder, A Frick, W Zieglgänsberger.   

Abstract

In a direct approach to elucidate the origin of long-term depression (LTD), glutamate was applied onto dendrites of neurons in rat neocortical slices. An infrared-guided laser stimulation was used to release glutamate from caged glutamate in the focal spot of an ultraviolet laser. A burst of light flashes caused an LTD-like depression of glutamate receptor responses, which was highly confined to the region of "tetanic" stimulation (<10 micrometers). A similar depression of glutamate receptor responses was observed during LTD of synaptic transmission. A spatially highly specific postsynaptic mechanism can account for the LTD induced by glutamate release.

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Year:  1999        PMID： 10506556     DOI： 10.1126/science.286.5437.110

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  27 in total

Review 1.  [What do we know about the state of chronic pain?].

Authors:  S C Azad; W Zieglgänsberger
Journal:  Schmerz       Date:  2003-12       Impact factor: 1.107

2.  Heterosynaptic long-term potentiation at GABAergic synapses of spinal lamina I neurons.

Authors:  Henning Fenselau; Bernhard Heinke; Jürgen Sandkühler
Journal:  J Neurosci       Date:  2011-11-30       Impact factor: 6.167

3.  Synaptic inputs and timing underlying the velocity tuning of direction-selective ganglion cells in rabbit retina.

Authors:  Benjamin Sivyer; Michiel van Wyk; David I Vaney; W Rowland Taylor
Journal:  J Physiol       Date:  2010-07-12       Impact factor: 5.182

4.  Uniformity detector retinal ganglion cells fire complex spikes and receive only light-evoked inhibition.

Authors:  Benjamin Sivyer; W Rowland Taylor; David I Vaney
Journal:  Proc Natl Acad Sci U S A       Date:  2010-03-08       Impact factor: 11.205

5.  Phase-gradient contrast in thick tissue with a scanning microscope.

Authors:  J Mertz; A Gasecka; A Daradich; I Davison; D Coté
Journal:  Biomed Opt Express       Date:  2014-01-08       Impact factor: 3.732

6.  Glycinergic interneurons are functionally integrated into the inspiratory network of mouse medullary slices.

Authors:  Stefan M Winter; Jens Fresemann; Christian Schnell; Yoshitaka Oku; Johannes Hirrlinger; Swen Hülsmann
Journal:  Pflugers Arch       Date:  2009-02-24       Impact factor: 3.657

7.  The mechanism of presynaptic long-term depression mediated by group I metabotropic glutamate receptors.

Authors:  Yuansheng Tan; Nobuaki Hori; David O Carpenter
Journal:  Cell Mol Neurobiol       Date:  2003-04       Impact factor: 5.046

8.  Cell type-specific thalamic innervation in a column of rat vibrissal cortex.

Authors:  Hanno S Meyer; Verena C Wimmer; Mike Hemberger; Randy M Bruno; Christiaan P J de Kock; Andreas Frick; Bert Sakmann; Moritz Helmstaedter
Journal:  Cereb Cortex       Date:  2010-06-09       Impact factor: 5.357

9.  Targeted in vivo expression of proteins in the calyx of Held.

Authors:  Verena C Wimmer; Thomas Nevian; Thomas Kuner
Journal:  Pflugers Arch       Date:  2004-12       Impact factor: 3.657

10.  Versatile synthesis and rational design of caged morpholinos.

Authors:  Xiaohu Ouyang; Ilya A Shestopalov; Surajit Sinha; Genhua Zheng; Cameron L W Pitt; Wen-Hong Li; Andrew J Olson; James K Chen
Journal:  J Am Chem Soc       Date:  2009-09-23       Impact factor: 15.419
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