RATIONALE AND OBJECTIVES: In this paper we discuss novel MR imaging blood pool agents characterized by new pharmacokinetic properties. METHODS: The pharmacokinetics of the products were studied in a rabbit model. The potential of these new products was demonstrated in experimental MR imaging. RESULTS AND CONCLUSION: Three main classes of blood pool agents have been defined and characterized according to their pharmacokinetic properties: low diffusion agents, rapid clearance blood pool agents, slow clearance blood pool agents. Each kind of blood pool agent is expected to have different diagnostic applications.
RATIONALE AND OBJECTIVES: In this paper we discuss novel MR imaging blood pool agents characterized by new pharmacokinetic properties. METHODS: The pharmacokinetics of the products were studied in a rabbit model. The potential of these new products was demonstrated in experimental MR imaging. RESULTS AND CONCLUSION: Three main classes of blood pool agents have been defined and characterized according to their pharmacokinetic properties: low diffusion agents, rapid clearance blood pool agents, slow clearance blood pool agents. Each kind of blood pool agent is expected to have different diagnostic applications.
Authors: R B Lauffer; D J Parmelee; H S Ouellet; R P Dolan; H Sajiki; D M Scott; P J Bernard; E M Buchanan; K Y Ong; Z Tyeklár; K S Midelfort; T J McMurry; R C Walovitch Journal: Acad Radiol Date: 1996-08 Impact factor: 3.173
Authors: Bruno Marchand; Philippe C Douek; Philippe Robert; Claire Corot; Jean Pierre Roux; Patrice Adeleine; Marcela Hernandez-Hoyos; Yannick Cremillieux; Maciej Orkisz; Emmanuelle Canet Journal: MAGMA Date: 2002-06 Impact factor: 2.533
Authors: M Port; C Corot; O Rousseaux; I Raynal; L Devoldere; J M Idée; A Dencausse; S Le Greneur; C Simonot; D Meyer Journal: MAGMA Date: 2001-05 Impact factor: 2.533