Literature DB >> 10501237

Immune responses to Brugia malayi paramyosin in rodents after DNA vaccination.

B W Li1, S Zhang, K C Curtis, G J Weil.   

Abstract

Immunization with recombinant Brugia malayi paramyosin protein (BM5) induces partial immunity to this filarial nematode in jirds. The present study examined the effects of intramuscular immunization with plasmid DNA that encodes BM5. DNA-immunized mice produced strong antibody and cell-mediated responses to paramyosin. The protective activity of DNA vaccination with BM5 was tested in jirds. Vaccinated jirds produced strong antibody responses to paramyosin, but adult worm recoveries after challenge were not decreased in vaccinated animals relative to controls. These studies show that DNA vaccination can induce immune responses to filarial antigens in rodents. Further efforts will be needed to achieve the goal of inducing protective immunity to filariasis with this promising new technology.

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Year:  1999        PMID： 10501237     DOI： 10.1016/s0264-410x(99)00182-6

Source DB:  PubMed          Journal:  Vaccine        ISSN： 0264-410X            Impact factor:   3.641


  15 in total

1.  Brugia malayi: comparison of protective immune responses induced by Bm-alt-2 DNA, recombinant Bm-ALT-2 protein and prime-boost vaccine regimens in a jird model.

Authors:  Sivasakthivel Thirugnanam; Pandurangan Pandiaraja; Kalyanasundaram Ramaswamy; Vadivel Murugan; Munirathinam Gnanasekar; Krithika Nandakumar; Maryada Venkata Rami Reddy; Perumal Kaliraj
Journal:  Exp Parasitol       Date:  2007-03-06       Impact factor: 2.011

Review 2.  A comprehensive, model-based review of vaccine and repeat infection trials for filariasis.

Authors:  C Paul Morris; Holly Evans; Sasha E Larsen; Edward Mitre
Journal:  Clin Microbiol Rev       Date:  2013-07       Impact factor: 26.132

3.  The abundant larval transcript-1 and -2 genes of Brugia malayi encode stage-specific candidate vaccine antigens for filariasis.

Authors:  W F Gregory; A K Atmadja; J E Allen; R M Maizels
Journal:  Infect Immun       Date:  2000-07       Impact factor: 3.441

4.  DNA immunization with Na+-K+ ATPase (Sseat-6) induces protective immunity to larval Strongyloides stercoralis in mice.

Authors:  Laura A Kerepesi; Paul B Keiser; Thomas J Nolan; Gerhard A Schad; David Abraham; Thomas B Nutman
Journal:  Infect Immun       Date:  2005-04       Impact factor: 3.441

5.  Troponin 1 of human filarial parasite Brugia malayi: cDNA cloning, expression, purification, and its immunoprophylactic potential.

Authors:  Vikas Kushwaha; Prachi Tewari; Payal Mandal; Anurag Tripathi; P Kalpana Murthy
Journal:  Parasitol Res       Date:  2019-05-04       Impact factor: 2.289

6.  Novel phage display-based subtractive screening to identify vaccine candidates of Brugia malayi.

Authors:  Munirathinam Gnanasekar; Kakaturu V N Rao; Yi-Xun He; Pankaj K Mishra; Thomas B Nutman; Perumal Kaliraj; Kalyanasundaram Ramaswamy
Journal:  Infect Immun       Date:  2004-08       Impact factor: 3.441

7.  Protective immune responses to biolistic DNA vaccination of Brugia malayi abundant larval transcript-2.

Authors:  S K Joseph; S Sambanthamoorthy; G Dakshinamoorthy; G Munirathinam; K Ramaswamy
Journal:  Vaccine       Date:  2012-08-08       Impact factor: 3.641

8.  Molecular cloning, purification and characterisation of myosin of human lymphatic filarial parasite Brugia malayi.

Authors:  S K Verma; I Bansal; S Vedi; J K Saxena; V M Katoch; S M Bhattacharya
Journal:  Parasitol Res       Date:  2007-12-07       Impact factor: 2.289

9.  Host protective immunity and vaccine development studies in lymphatic filariasis.

Authors:  M V Reddy; R Alli; B C Harinath
Journal:  Indian J Clin Biochem       Date:  2000-08

10.  Antibody responses to Brugia malayi antigens induced by DNA vaccination.

Authors:  Ben-Wen Li; Amy Rush; Shaorong R Zhang; Kurt C Curtis; Gary J Weil
Journal:  Filaria J       Date:  2004-01-22
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