Literature DB >> 10501006

Arg-gingipain inhibition and anti-bacterial activity selective for Porphyromonas gingivalis by malabaricone C.

C Shinohara1, S Mori, T Ando, T Tsuji.   

Abstract

Effects of malabaricon C, isolated from nutmeg (Myristica fragrans), on Arg-gingipain activity and growth of several kinds of anaerobic and aerobic microorganisms were investigated. Malabaricone C irreversibly inhibited Arg-gingipain by 50% at a concentration of 0.7 microgram/ml and selectively suppressed Porphyromomas gingivalis growth.

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Year:  1999        PMID： 10501006     DOI： 10.1271/bbb.63.1475

Source DB:  PubMed          Journal:  Biosci Biotechnol Biochem        ISSN： 0916-8451            Impact factor:   2.043


  4 in total

1.  Chemical diversity and pharmacological significance of the secondary metabolites of nutmeg (Myristica fragrans Houtt.).

Authors:  Ehab A Abourashed; Abir T El-Alfy
Journal:  Phytochem Rev       Date:  2016-05-10       Impact factor: 5.374

2.  Phenolic compounds from nutmeg (Myristica fragrans Houtt.) inhibit the endocannabinoid-modulating enzyme fatty acid amide hydrolase.

Authors:  Abir T El-Alfy; Ehab A Abourashed; Christina Patel; Nunmoula Mazhari; HeaRe An; Andrew Jeon
Journal:  J Pharm Pharmacol       Date:  2019-10-08       Impact factor: 3.765

Review 3.  Implications of Porphyromonas gingivalis peptidyl arginine deiminase and gingipain R in human health and diseases.

Authors:  Yoke Chan Chow; Hok Chai Yam; Baskaran Gunasekaran; Weng Yeen Lai; Weng Yue Wo; Tarun Agarwal; Yien Yien Ong; Siew Lee Cheong; Sheri-Ann Tan
Journal:  Front Cell Infect Microbiol       Date:  2022-09-29       Impact factor: 6.073

4.  Antibacterial Activity of Myristica fragrans against Oral Pathogens.

Authors:  Zaleha Shafiei; Nadia Najwa Shuhairi; Nordiyana Md Fazly Shah Yap; Carrie-Anne Harry Sibungkil; Jalifah Latip
Journal:  Evid Based Complement Alternat Med       Date:  2012-08-28       Impact factor: 2.629
  4 in total

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