Literature DB >> 10500132

A chemically labeled cytotoxic agent: two-photon fluorophore for optical tracking of cellular pathway in chemotherapy.

X Wang1, L J Krebs, M Al-Nuri, H E Pudavar, S Ghosal, C Liebow, A A Nagy, A V Schally, P N Prasad.   

Abstract

Chemotherapy is commonly used in the treatment of cancers. However, the mechanism of action of many of these agents is not well understood. We present the synthesis of a two-photon fluorophore (C625) and its biological application when chemically linked to a chemotherapeutic agent (AN-152). By using two-photon laser-scanning microscopy, the drug:fluorophore conjugate can be observed directly as it interacts with receptor-positive cell lines. The results of this project visually show the receptor-mediated entry of AN-152 into the cell cytoplasm and subsequently into the nucleus. These observations will allow for better understanding of the drug's therapeutic mechanism, which is a subject of ongoing research aimed at improving present methods for cancer therapy.

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Year:  1999        PMID： 10500132      PMCID： PMC17989          DOI： 10.1073/pnas.96.20.11081

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  22 in total

1.  Two-photon-excitation fluorescence imaging of three-dimensional calcium-ion activity.

Authors:  D W Piston; M S Kirby; H Cheng; W J Lederer; W W Webb
Journal:  Appl Opt       Date:  1994-02-01       Impact factor: 1.980

2.  Two-photon absorption and optical-limiting properties of novel organic compounds.

Authors:  G S He; G C Xu; P N Prasad; B A Reinhardt; J C Bhatt; A G Dillard
Journal:  Opt Lett       Date:  1995-03-01       Impact factor: 3.776

3.  Three-dimensional laser scanning two-photon fluorescence confocal microscopy of polymer materials using a new, efficient upconverting fluorophore.

Authors:  J D Bhawalkar; J Swiatkiewicz; S J Pan; J K Samarabandu; W S Liou; G S He; R Berezney; P C Cheng; P N Prasad
Journal:  Scanning       Date:  1996-11       Impact factor: 1.932

4.  Two-photon laser scanning fluorescence microscopy.

Authors:  W Denk; J H Strickler; W W Webb
Journal:  Science       Date:  1990-04-06       Impact factor: 47.728

Review 5.  Expression and signal transduction pathways of gonadotropin-releasing hormone receptors.

Authors:  S S Stojilkovic; K J Catt
Journal:  Recent Prog Horm Res       Date:  1995

6.  A confocal laser scanning microscope designed for indicators with ultraviolet excitation wavelengths.

Authors:  E Niggli; D W Piston; M S Kirby; H Cheng; D R Sandison; W W Webb; W J Lederer
Journal:  Am J Physiol       Date:  1994-01

Review 7.  Two-photon molecular excitation provides intrinsic 3-dimensional resolution for laser-based microscopy and microphotochemistry.

Authors:  R M Williams; D W Piston; W W Webb
Journal:  FASEB J       Date:  1994-08       Impact factor: 5.191

8.  Growth inhibition of human ovarian cancers by cytotoxic analogues of luteinizing hormone-releasing hormone.

Authors:  M Miyazaki; A Nagy; A V Schally; N Lamharzi; G Halmos; K Szepeshazi; K Groot; P Armatis
Journal:  J Natl Cancer Inst       Date:  1997-12-03       Impact factor: 13.506

9.  Highly potent analogues of luteinizing hormone-releasing hormone containing D-phenylalanine nitrogen mustard in position 6.

Authors:  S Bajusz; T Janaky; V J Csernus; L Bokser; M Fekete; G Srkalovic; T W Redding; A V Schally
Journal:  Proc Natl Acad Sci U S A       Date:  1989-08       Impact factor: 11.205

10.  Evaluation of binding of cytotoxic analogs of luteinizing hormone-releasing hormone to human breast cancer and mouse MXT mammary tumor.

Authors:  S R Milovanovic; S Radulovic; A V Schally
Journal:  Breast Cancer Res Treat       Date:  1992       Impact factor: 4.872
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  6 in total

1.  Introduction of D-phenylalanine enhanced the receptor binding affinities of gonadotropin-releasing hormone peptides.

Authors:  Jie Lu; Helen J Hathaway; Melanie E Royce; Eric R Prossnitz; Yubin Miao
Journal:  Bioorg Med Chem Lett       Date:  2014-01-06       Impact factor: 2.823

2.  Synthesis and evaluation of novel gonadotropin-releasing hormone receptor-targeting peptides.

Authors:  Haixun Guo; Jie Lu; Helen Hathaway; Melanie E Royce; Eric R Prossnitz; Yubin Miao
Journal:  Bioconjug Chem       Date:  2011-07-20       Impact factor: 4.774

3.  Combinatorial discovery of two-photon photoremovable protecting groups.

Authors:  Michael C Pirrung; Wolfgang H Pieper; Krishna P Kaliappan; Mugunthu R Dhananjeyan
Journal:  Proc Natl Acad Sci U S A       Date:  2003-10-13       Impact factor: 11.205

4.  Fluorescent coumarin derivatives with viscosity sensitive emission--synthesis, photophysical properties and computational studies.

Authors:  Kiran R Phatangare; Sandip K Lanke; Nagaiyan Sekar
Journal:  J Fluoresc       Date:  2014-06-03       Impact factor: 2.217

5.  Physical Mechanisms of Intermolecular Interactions and Cross-Space Charge Transfer in Two-Photon BDBT-TCNB Co-Crystals.

Authors:  Chen Lu; Ning Li; Ying Jin; Ying Sun; Jingang Wang
Journal:  Nanomaterials (Basel)       Date:  2022-08-11       Impact factor: 5.719

6.  Targeted cytotoxic analog of luteinizing hormone-releasing hormone (LHRH), AEZS-108 (AN-152), inhibits the growth of DU-145 human castration-resistant prostate cancer in vivo and in vitro through elevating p21 and ROS levels.

Authors:  Petra Popovics; Andrew V Schally; Luca Szalontay; Norman L Block; Ferenc G Rick
Journal:  Oncotarget       Date:  2014-06-30
  6 in total

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