| Literature DB >> 10499580 |
C Rodríguez Esteban1, J Capdevila, A N Economides, J Pascual, A Ortiz, J C Izpisúa Belmonte.
Abstract
In the chick embryo, left-right asymmetric patterns of gene expression in the lateral plate mesoderm are initiated by signals located in and around Hensen's node. Here we show that Caronte (Car), a secreted protein encoded by a member of the Cerberus/Dan gene family, mediates the Sonic hedgehog (Shh)-dependent induction of left-specific genes in the lateral plate mesoderm. Car is induced by Shh and repressed by fibroblast growth factor-8 (FGF-8). Car activates the expression of Nodal by antagonizing a repressive activity of bone morphogenic proteins (BMPs). Our results define a complex network of antagonistic molecular interactions between Activin, FGF-8, Lefty-1, Nodal, BMPs and Car that cooperate to control left-right asymmetry in the chick embryo.Entities:
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Year: 1999 PMID： 10499580 DOI： 10.1038/45738
Source DB: PubMed Journal: Nature ISSN： 0028-0836 Impact factor: 49.962