| Literature DB >> 10499338 |
M G Schmid1, M Laffranchini, D Dreveny, G Gübitz.
Abstract
A rapid and simple approach to the chiral separation of sympathomimetic drugs with amino alcohol structure by ligand exchange capillary electrophoresis is described. An N-(2-hydroxyoctyl)-L-4-hydroxyproline/copper(II) complex is used as chiral selector. Thirteen sympathomimetics were resolved, nine with baseline resolution. The influence of pH and composition of the electrolyte on resolution was investigated. The optimal pH for complexation of these amino alcohols was found to be 12.Entities:
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Year: 1999 PMID： 10499338 DOI： 10.1002/(SICI)1522-2683(19990801)20:12<2458::AID-ELPS2458>3.0.CO;2-8
Source DB: PubMed Journal: Electrophoresis ISSN： 0173-0835 Impact factor: 3.535