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Literature DB >> 10498735

4,4'-diapophytoene desaturase: catalytic properties of an enzyme from the C(30) carotenoid pathway of Staphylococcus aureus.

Abstract

Staphylococcus aureus synthesizes C(30) carotenoids. Their formation involves the introduction of three double bonds, which is catalyzed by a single enzyme. This enzyme, 4,4'-diapophytoene desaturase from S. aureus, was overexpressed in Escherichia coli and purified in one step by affinity chromatography, and then the protein was characterized with respect to substrate specificity, cofactor requirement, and oligomerization.

Entities: Chemical Species

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Year: 1999 PMID： 10498735 PMCID： PMC103650 DOI： 10.1128/JB.181.19.6184-6187.1999

Source DB: PubMed Journal: J Bacteriol ISSN： 0021-9193 Impact factor: 3.490

11 in total

1. A single polypeptide catalyzing the conversion of phytoene to zeta-carotene is transcriptionally regulated during tomato fruit ripening.

Authors: I Pecker; D Chamovitz; H Linden; G Sandmann; J Hirschberg
Journal: Proc Natl Acad Sci U S A Date: 1992-06-01 Impact factor: 11.205

2. The nucleotide sequence of pACYC184.

Authors: R E Rose
Journal: Nucleic Acids Res Date: 1988-01-11 Impact factor: 16.971

3. The major carotenoid in all known species of heliobacteria is the C30 carotenoid 4,4'-diaponeurosporene, not neurosporene.

Authors: S Takaichi; K Inoue; M Akaike; M Kobayashi; H Oh-oka; M T Madigan
Journal: Arch Microbiol Date: 1997-10 Impact factor: 2.552

Review 4. Carotenoid biosynthesis in microorganisms and plants.

Authors: G Sandmann
Journal: Eur J Biochem Date: 1994-07-01

Review 5. Bacterial triterpenoids.

Authors: R F Taylor
Journal: Microbiol Rev Date: 1984-09

6. Proposed pathway of triterpenoid carotenoid biosynthesis in Staphylococcus aureus: evidence from a study of mutants.

Authors: J H Marshall; G J Wilmoth
Journal: J Bacteriol Date: 1981-09 Impact factor: 3.490

7. Pigments of Staphylococcus aureus, a series of triterpenoid carotenoids.

Authors: J H Marshall; G J Wilmoth
Journal: J Bacteriol Date: 1981-09 Impact factor: 3.490

8. Purification in an active state and properties of the 3-step phytoene desaturase from Rhodobacter capsulatus overexpressed in Escherichia coli.

Authors: A Raisig; G Bartley; P Scolnik; G Sandmann
Journal: J Biochem Date: 1996-03 Impact factor: 3.387

9. Triterpenoid carotenoids and related lipids. The triterpenoid carotenes of Streptococcus faecium UNH 564P.

Authors: R F Taylor; B H Davies
Journal: Biochem J Date: 1974-06 Impact factor: 3.857

10. Genetic and biochemical analyses of the biosynthesis of the yellow carotenoid 4,4'-diaponeurosporene of Staphylococcus aureus.

Authors: B Wieland; C Feil; E Gloria-Maercker; G Thumm; M Lechner; J M Bravo; K Poralla; F Götz
Journal: J Bacteriol Date: 1994-12 Impact factor: 3.490

8 in total

4,4'-diapophytoene desaturase: catalytic properties of an enzyme from the C(30) carotenoid pathway of Staphylococcus aureus.

1. A single polypeptide catalyzing the conversion of phytoene to zeta-carotene is transcriptionally regulated during tomato fruit ripening.

2. The nucleotide sequence of pACYC184.

3. The major carotenoid in all known species of heliobacteria is the C30 carotenoid 4,4'-diaponeurosporene, not neurosporene.

Review 4. Carotenoid biosynthesis in microorganisms and plants.

Review 5. Bacterial triterpenoids.

6. Proposed pathway of triterpenoid carotenoid biosynthesis in Staphylococcus aureus: evidence from a study of mutants.

7. Pigments of Staphylococcus aureus, a series of triterpenoid carotenoids.

8. Purification in an active state and properties of the 3-step phytoene desaturase from Rhodobacter capsulatus overexpressed in Escherichia coli.

9. Triterpenoid carotenoids and related lipids. The triterpenoid carotenes of Streptococcus faecium UNH 564P.

10. Genetic and biochemical analyses of the biosynthesis of the yellow carotenoid 4,4'-diaponeurosporene of Staphylococcus aureus.

1. CspA regulates pigment production in Staphylococcus aureus through a SigB-dependent mechanism.

Review 2. Mechanistic aspects of carotenoid biosynthesis.

3. Small-molecule targeting of a diapophytoene desaturase inhibits S. aureus virulence.

4. Sigma(B) activity depends on RsbU in Staphylococcus aureus.

5. Preparation, characterization, and optimization of an in vitro C30 carotenoid pathway.

6. Biosynthesis of ubiquinone compounds with conjugated prenyl side chains.

7. Analysis of al-2 mutations in Neurospora.

8. Dehydrosqualene Desaturase as a Novel Target for Anti-Virulence Therapy against Staphylococcus aureus.