| Literature DB >> 10498211 |
S Y Tamura1, E A Goldman, P W Bergum, J E Semple.
Abstract
Rigid benzolactam P3-P2 dipeptide mimics were designed and prepared as potential inhibitors of blood coagulation factor Xa. Methoxy substitution of the tetrahydrobenzazepinone scaffold led to potent and selective inhibitors. The synthesis and biological activities of these derivatives are reported herein.Entities:
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Year: 1999 PMID： 10498211 DOI： 10.1016/s0960-894x(99)00417-5
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823