| Literature DB >> 10498189 |
R J Harrison1, S M Gowan, L R Kelland, S Neidle.
Abstract
A series of 3,6-disubstituted acridine derivatives have been rationally designed as telomerase inhibitors. They have been designed on the basis that inhibition of telomerase occurs by stabilising G-quadruplex structures formed by the folding of telomeric DNA. The most potent inhibitors have IC50 values against telomerase of between 1.3 and 8 microM, comparable to their cytotoxicity in ovarian cancer cell lines.Entities:
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Year: 1999 PMID： 10498189 DOI： 10.1016/s0960-894x(99)00394-7
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823