| Literature DB >> 10498047 |
E R Dixon1, J A Weinberg, D B Lew.
Abstract
Airway smooth muscle proliferation is a key component of airway wall remodelling that occurs as a consequence of inflammation in asthma. Studies were conducted to examine the effect of dexamethasone on airway smooth muscle cell (ASMC) proliferation in vitro. Dexamethasone (25-250 nM) significantly inhibited DNA synthesis and cell division induced by beta-hexosaminidase A (Hex A, 50 nM) in bovine ASMC. The inhibitory effect of dexamethasone on DNA synthesis was variable depending on the growth factors: significant effect was observed on Hex A and insulin; no significant effect was observed on epidermal growth factor and fetal bovine serum.Entities:
Mesh：
Substances：
Year: 1999 PMID： 10498047 DOI： 10.3109/02770909909054558
Source DB: PubMed Journal: J Asthma ISSN： 0277-0903 Impact factor: 2.515