Literature DB >> 10497988

Short report: effects of pyronaridine on gametocytes in patients with acute uncomplicated falciparum malaria.

P Ringwald1, F S Meche, L K Basco.   

Abstract

The effects of pyronaridine and chloroquine on mature Plasmodium falciparum gametocytes were compared in 161 patients treated with chloroquine or pyronaridine. Neither pyronaridine nor chloroquine showed gametocytocidal activity. The relative risks of post-treatment gametocytemia after pyronaridine and chloroquine treatment in the presence of chloroquine-resistant isolates were 1.25 and 11.5, respectively, suggesting that the use of chloroquine was associated with a high risk of favoring post-therapeutic gametocytemia in chloroquine-resistant infections.

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Year:  1999        PMID： 10497988     DOI： 10.4269/ajtmh.1999.61.446

Source DB:  PubMed          Journal:  Am J Trop Med Hyg        ISSN： 0002-9637            Impact factor:   2.345


  7 in total

1.  Transmission-blocking activities of quinine, primaquine, and artesunate.

Authors:  Kesinee Chotivanich; Jetsumon Sattabongkot; Rachanee Udomsangpetch; Sornchai Looareesuwan; Nicholas P J Day; Russell E Coleman; Nicholas J White
Journal:  Antimicrob Agents Chemother       Date:  2006-06       Impact factor: 5.191

Review 2.  Artemisinin-based combination therapies: a vital tool in efforts to eliminate malaria.

Authors:  Richard T Eastman; David A Fidock
Journal:  Nat Rev Microbiol       Date:  2009-11-02       Impact factor: 60.633

Review 3.  Strategic use of antimalarial drugs that block falciparum malaria parasite transmission to mosquitoes to achieve local malaria elimination.

Authors:  Rashad Abdul-Ghani; John C Beier
Journal:  Parasitol Res       Date:  2014-09-04       Impact factor: 2.289

Review 4.  Pyronaridine-artesunate for treating uncomplicated Plasmodium falciparum malaria.

Authors:  Joseph Pryce; Melissa Taylor; Tilly Fox; Paul Hine
Journal:  Cochrane Database Syst Rev       Date:  2022-06-21

5.  Review of pyronaridine anti-malarial properties and product characteristics.

Authors:  Simon L Croft; Stephan Duparc; Sarah J Arbe-Barnes; J Carl Craft; Chang-Sik Shin; Lawrence Fleckenstein; Isabelle Borghini-Fuhrer; Han-Jong Rim
Journal:  Malar J       Date:  2012-08-09       Impact factor: 2.979

6.  Pyronaridine-artesunate for treating uncomplicated Plasmodium falciparum malaria.

Authors:  Joseph Pryce; Paul Hine
Journal:  Cochrane Database Syst Rev       Date:  2019-01-08

7.  Inclusion of gametocyte parameters in anti-malarial drug efficacy studies: filling a neglected gap needed for malaria elimination.

Authors:  Rashad Abdul-Ghani; Leonardo K Basco; John C Beier; Mohammed A K Mahdy
Journal:  Malar J       Date:  2015-10-19       Impact factor: 2.979
  7 in total

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