PURPOSE: Amylose derivatives form an important group of polymers, and many of them can be used as drug sustained-release systems. METHODS: Substituted amylose can be prepared in a 1-step reaction with substituent(s) in a basic medium. The substituents can be represented as (A-R), where (A) serves an epoxy, halide or suitable organic or inorganic function reacting with hydroxyl groups located on the amylose chain, and (R) is an organic radical. RESULTS: The present work shows the synthesis of different polymers and the effect of different (A) and/or (R) and their different degrees of substitution (n) on the sustained drug release from matrix tablets prepared by direct compression. CONCLUSIONS: SA polymers are interesting excipients for the preparation of controlled drug release tablets.
PURPOSE:Amylose derivatives form an important group of polymers, and many of them can be used as drug sustained-release systems. METHODS: Substituted amylose can be prepared in a 1-step reaction with substituent(s) in a basic medium. The substituents can be represented as (A-R), where (A) serves an epoxy, halide or suitable organic or inorganic function reacting with hydroxyl groups located on the amylose chain, and (R) is an organic radical. RESULTS: The present work shows the synthesis of different polymers and the effect of different (A) and/or (R) and their different degrees of substitution (n) on the sustained drug release from matrix tablets prepared by direct compression. CONCLUSIONS:SA polymers are interesting excipients for the preparation of controlled drug release tablets.