Literature DB >> 10496287

No association of paraoxonase gene polymorphism with atherosclerosis or Alzheimer's disease.

N Sodeyama1, M Yamada, Y Itoh, N Suematsu, M Matsushita, E Otomo, H Mizusawa.   

Abstract

Both AD and paraoxonase (PON) have been reported to be related to lipids and atherosclerosis, suggesting that the PON gene (PON) is a possible genetic risk factor for AD. We found no association of PON polymorphism with severity of atherosclerosis, densities of AD-type, neuropathologic change, or development of AD in 47 AD and 90 nondemented patients. Our study suggests that PON polymorphism does not play a causal role in the development of atherosclerosis or AD.

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Year:  1999        PMID： 10496287     DOI： 10.1212/wnl.53.5.1146

Source DB:  PubMed          Journal:  Neurology        ISSN： 0028-3878            Impact factor:   9.910


  4 in total

1.  Serum paraoxonase activity is associated with variants in the PON gene cluster and risk of Alzheimer disease.

Authors:  Porat M Erlich; Kathryn L Lunetta; L Adrienne Cupples; Carmela R Abraham; Robert C Green; Clinton T Baldwin; Lindsay A Farrer
Journal:  Neurobiol Aging       Date:  2010-10-27       Impact factor: 4.673

2.  Association between paraoxonase-1 gene polymorphisms and risk of metabolic syndrome.

Authors:  Dor Mohammad Kordi-Tamandani; Mohammad Hashemi; Nooshin Sharifi; Mahmoud Ali Kaykhaei; Adam Torkamanzehi
Journal:  Mol Biol Rep       Date:  2011-05-15       Impact factor: 2.316

3.  Association of a polymorphism of the transforming growth factor-beta1 gene with cerebral amyloid angiopathy.

Authors:  T Hamaguchi; S Okino; N Sodeyama; Y Itoh; A Takahashi; E Otomo; M Matsushita; H Mizusawa; M Yamada
Journal:  J Neurol Neurosurg Psychiatry       Date:  2005-05       Impact factor: 10.154

4.  Profile of the Paraoxonase 1 (PON1) Gene 192Q/R Polymorphism and Clinical Associations among Older Singaporean Chinese with Alzheimer's and Mixed Dementia.

Authors:  Dennis C C Seow; Qi Gao; Philip Yap; Jia Min Gan; Hui Ling Chionh; Su Chi Lim; Lei Feng; Tze Pin Ng
Journal:  Dement Geriatr Cogn Dis Extra       Date:  2016-02-17
  4 in total

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