OBJECTIVE: To examine the intrathecal production of a newly identified cytokine, interferon-gamma-inducing factor (IL-18), together with interferon-gamma itself, in inflammatory diseases of the CNS (i.e., bacterial meningitis, viral meningoencephalitis, and MS). RESULTS: IL-18 concentrations in CSF were significantly increased in bacterial meningitis and tended toward increased levels in viral meningoencephalitis. In contrast, IL-18 was detectable only in a few patients with MS and healthy controls. Interestingly, interferon-gamma was significantly increased selectively in CSF of patients with viral meningoencephalitis. CONCLUSION: The observation of an intrathecal release of IL-18 in patients with meningitis argues for a pathophysiologic role of this novel cytokine in immunity against invading microorganisms the CNS.
OBJECTIVE: To examine the intrathecal production of a newly identified cytokine, interferon-gamma-inducing factor (IL-18), together with interferon-gamma itself, in inflammatory diseases of the CNS (i.e., bacterial meningitis, viral meningoencephalitis, and MS). RESULTS:IL-18 concentrations in CSF were significantly increased in bacterial meningitis and tended toward increased levels in viral meningoencephalitis. In contrast, IL-18 was detectable only in a few patients with MS and healthy controls. Interestingly, interferon-gamma was significantly increased selectively in CSF of patients with viral meningoencephalitis. CONCLUSION: The observation of an intrathecal release of IL-18 in patients with meningitis argues for a pathophysiologic role of this novel cytokine in immunity against invading microorganisms the CNS.
Authors: Vyacheslav Y Melnikov; Sarah Faubel; Britta Siegmund; M Scott Lucia; Danica Ljubanovic; Charles L Edelstein Journal: J Clin Invest Date: 2002-10 Impact factor: 14.808
Authors: Tik Muk; Allan Stensballe; Stanislava Pankratova; Duc Ninh Nguyen; Anders Brunse; Per Torp Sangild; Ping-Ping Jiang Journal: Front Immunol Date: 2019-11-15 Impact factor: 7.561
Authors: Eleanor Cape; Roanna J Hall; Barbara C van Munster; Annick de Vries; Sarah E M Howie; Andrew Pearson; Scott D Middleton; Fiona Gillies; Ian R Armstrong; Tim O White; Colm Cunningham; Sophia E de Rooij; Alasdair M J MacLullich Journal: J Psychosom Res Date: 2014-07-04 Impact factor: 3.006