Literature DB >> 10494846

Diphosphoinositol polyphosphates: the final frontier for inositide research?

S T Safrany1, J J Caffrey, X Yang, S B Shears.   

Abstract

The diphosphoinositol polyphosphates comprise a group of highly phosphorylated compounds which have a rapid rate of metabolic turnover through tightly-regulated kinase/phosphohydrolase substrate cycles. The phosphohydrolases occur as multiple isoforms, the expression of which is apparently carefully controlled. Cellular levels of the diphosphoinositol polyphosphates are regulated by cAMP and cGMP in a protein kinase-independent manner. These inositides can also sense a specific mode of intracellular Ca2+ pool depletion. In this review, we will argue that these are characteristics of highly significant cellular molecules.

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Year:  1999        PMID： 10494846     DOI： 10.1515/BC.1999.117

Source DB:  PubMed          Journal:  Biol Chem        ISSN： 1431-6730            Impact factor:   3.915


  7 in total

1.  Targeted deletion of Minpp1 provides new insight into the activity of multiple inositol polyphosphate phosphatase in vivo.

Authors:  H Chi; X Yang; P D Kingsley; R J O'Keefe; J E Puzas; R N Rosier; S B Shears; P R Reynolds
Journal:  Mol Cell Biol       Date:  2000-09       Impact factor: 4.272

Review 2.  How versatile are inositol phosphate kinases?

Authors:  Stephen B Shears
Journal:  Biochem J       Date:  2004-01-15       Impact factor: 3.857

3.  Paralogous murine Nudt10 and Nudt11 genes have differential expression patterns but encode identical proteins that are physiologically competent diphosphoinositol polyphosphate phosphohydrolases.

Authors:  Len V Hua; Kiyoshi Hidaka; Xavier Pesesse; Larry D Barnes; Stephen B Shears
Journal:  Biochem J       Date:  2003-07-01       Impact factor: 3.857

4.  Disruption and overexpression of the Schizosaccharomyces pombe aps1 gene, and effects on growth rate, morphology and intracellular diadenosine 5',5"'-P1,P5-pentaphosphate and diphosphoinositol polyphosphate concentrations.

Authors:  Stephen W Ingram; Stephen T Safrany; Larry D Barnes
Journal:  Biochem J       Date:  2003-02-01       Impact factor: 3.857

5.  Origin and seed phenotype of maize low phytic acid 1-1 and low phytic acid 2-1.

Authors:  V Raboy; P F Gerbasi; K A Young; S D Stoneberg; S G Pickett; A T Bauman; P P Murthy; W F Sheridan; D S Ertl
Journal:  Plant Physiol       Date:  2000-09       Impact factor: 8.340

Review 6.  Protein-lipid interactions and phosphoinositide metabolism in membrane traffic: insights from vesicle recycling in nerve terminals.

Authors:  Markus R Wenk; Pietro De Camilli
Journal:  Proc Natl Acad Sci U S A       Date:  2004-05-14       Impact factor: 11.205

7.  The genetics of phytate and phosphate accumulation in seeds and leaves of Arabidopsis thaliana, using natural variation.

Authors:  L Bentsink; K Yuan; M Koornneef; D Vreugdenhil
Journal:  Theor Appl Genet       Date:  2002-12-18       Impact factor: 5.699
  7 in total

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