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Literature DB >> 10493115

Novel canine tumour suppressor gene p53 mutations in cases of skin and mammary neoplasms.

Abstract

Exons 4 to 8 of the tumour suppressor gene p53 were analysed in 25 skin and 25 mammary tumours of 50 dogs. A 1 bp deletion (ACC-->AC) was detected in codon 89 in exon 4 in a squamous cell carcinoma. A missense mutation CGC-->CAC (arginine-->histidine) was present in codon 162 in exon 5 in a mammary adenocarcinoma. Moreover, a silent mutation occurred in codon 103 (serine) of exon 4 in a mammary adenoma. The somatic nature of the three mutations was demonstrated.

Entities: Chemical Disease Gene Species

Mesh：

Substances：

Year: 1999 PMID： 10493115 DOI： 10.1023/a:1006314903272

Source DB: PubMed Journal: Vet Res Commun ISSN： 0165-7380 Impact factor: 2.459

14 in total

1. An efficient salt-chloroform extraction of DNA from blood and tissues.

Authors: R Müllenbach; P J Lagoda; C Welter
Journal: Trends Genet Date: 1989-12 Impact factor: 11.639

2. P53 mutations in mammary tumor cell lines and corresponding tumor tissues in the dog.

Authors: I S Van Leeuwen; E Hellmèn; C J Cornelisse; B Van den Burgh; G R Rutteman
Journal: Anticancer Res Date: 1996 Nov-Dec Impact factor: 2.480

Review 3. Structural aspects of the p53 protein in relation to gene evolution: a second look.

Authors: T Soussi; P May
Journal: J Mol Biol Date: 1996-08-02 Impact factor: 5.469

4. Mutations of the p53 gene in canine lymphoma and evidence for germ line p53 mutations in the dog.

Authors: N Veldhoen; J Stewart; R Brown; J Milner
Journal: Oncogene Date: 1998-01-15 Impact factor: 9.867

5. Mutation of the p53 tumor suppressor gene in spontaneously occurring osteosarcomas of the dog.

Authors: A S Johnson; C G Couto; C M Weghorst
Journal: Carcinogenesis Date: 1998-01 Impact factor: 4.944

6. Isolation of canine p53 cDNA and detailed characterization of the full length canine p53 protein.

Authors: N Veldhoen; J Milner
Journal: Oncogene Date: 1998-02-26 Impact factor: 9.867

7. Cytogenetic alterations in eight mammary tumors and tumor-suppressor gene p53 mutation in one mammary tumor from dogs.

Authors: B Mayr; A Dressler; M Reifinger; C Feil
Journal: Am J Vet Res Date: 1998-01 Impact factor: 1.156

Novel canine tumour suppressor gene p53 mutations in cases of skin and mammary neoplasms.

1. An efficient salt-chloroform extraction of DNA from blood and tissues.

2. P53 mutations in mammary tumor cell lines and corresponding tumor tissues in the dog.

Review 3. Structural aspects of the p53 protein in relation to gene evolution: a second look.

4. Mutations of the p53 gene in canine lymphoma and evidence for germ line p53 mutations in the dog.

5. Mutation of the p53 tumor suppressor gene in spontaneously occurring osteosarcomas of the dog.

6. Isolation of canine p53 cDNA and detailed characterization of the full length canine p53 protein.

7. Cytogenetic alterations in eight mammary tumors and tumor-suppressor gene p53 mutation in one mammary tumor from dogs.

8. Sequence of an exon of the canine p53 gene--mutation in a papilloma.

9. The canine p53 gene is subject to somatic mutations in thypoid carcinoma.

Review 10. Mutations in the p53 tumor suppressor gene: clues to cancer etiology and molecular pathogenesis.

1. Mutations of p53 Gene in Canine Sweat Gland Carcinomas Probably Associated with UV Radiation.