| Literature DB >> 10492750 |
R V Cunha1, H G Schatzmayr, M P Miagostovich, A M Barbosa, F G Paiva, R M Miranda, C C Ramos, J C Coelho, F B dos Santos, R M Nogueira.
Abstract
During 1997 a large dengue epidemic occurred in Rio Grande do Norte, a State in north-east Brazil. The co-circulation of dengue virus type 1 and dengue virus type 2 was demonstrated by virus isolation in Aedes albopictus clone C6/36 cell-line and by reverse transcriptase-polymerase chain reaction (RT-PCR). IgM capture enzyme-linked immunosorbent assay confirmed 52.3% of the 8105 studied cases and dengue antigen was demonstrated by immunohistochemical reaction on hepatocytes from 2 out of 5 fatal cases studied. Individual risk factors for development of dengue haemorrhagic fever/dengue shock syndrome, such as hypertension, diabetes mellitus and bronchial asthma, are discussed.Entities:
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Year: 1999 PMID: 10492750 DOI: 10.1016/s0035-9203(99)90008-1
Source DB: PubMed Journal: Trans R Soc Trop Med Hyg ISSN: 0035-9203 Impact factor: 2.184