Literature DB >> 10492112

Are we prescribing multiple courses of antenatal corticosteroids? A survey of practice in the UK.

P Brocklehurst1, S Gates, K McKenzie-McHarg, Z Alfirevic, G Chamberlain.   

Abstract

A postal questionnaire concerned with prescribing antenatal corticosteroids was sent to one named clinician at each of 279 obstetric units in the UK. They were asked whether their unit prescribed repeated courses, the indications for which these would be prescribed, the interval between courses, the drugs and regimens used and whether they would be willing to participate in a proposed randomised controlled trial. The response rate was 75%. Of the respondents, 98% prescribed repeated courses; the indications most commonly cited by units who prescribed steroids were prelabour spontaneous rupture of membranes (84.2%) and suspected preterm labour (81.8%). 70.6% of units were willing to participate in the proposed trial.

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Year:  1999        PMID: 10492112     DOI: 10.1111/j.1471-0528.1999.tb08440.x

Source DB:  PubMed          Journal:  Br J Obstet Gynaecol        ISSN: 0306-5456


  23 in total

1.  Antenatal corticosteroids to prevent neonatal respiratory distress syndrome. We do not know whether repeated doses are better than a single dose.

Authors:  C Spencer; K Neales
Journal:  BMJ       Date:  2000-02-05

2.  Effects of multiple courses of antenatal steroids are uncertain.

Authors:  P Brocklehurst; S Gates; A Johnson; Z Alfirevic; G Chamberlain
Journal:  BMJ       Date:  2000-07-01

3.  Developmental regulation of the 5-HT7 serotonin receptor and transcription factor NGFI-A in the fetal guinea-pig limbic system: influence of GCs.

Authors:  Marcus H Andrews; Alice Kostaki; Elaine Setiawan; Lucy McCabe; Dawn Owen; Sonja Banjanin; Stephen G Matthews
Journal:  J Physiol       Date:  2004-01-14       Impact factor: 5.182

Review 4.  Fetal programming of hypothalamo-pituitary-adrenal function: prenatal stress and glucocorticoids.

Authors:  Amita Kapoor; Elizabeth Dunn; Alice Kostaki; Marcus H Andrews; Stephen G Matthews
Journal:  J Physiol       Date:  2006-02-09       Impact factor: 5.182

Review 5.  Decline in effectiveness of antenatal corticosteroids with time to birth: real or artefact?

Authors:  Simon Gates; Peter Brocklehurst
Journal:  BMJ       Date:  2007-07-14

Review 6.  Glucocorticoids and fetal programming part 1: Outcomes.

Authors:  Vasilis G Moisiadis; Stephen G Matthews
Journal:  Nat Rev Endocrinol       Date:  2014-05-27       Impact factor: 43.330

7.  Repeated maternal glucocorticoid treatment affects activity and hippocampal NMDA receptor expression in juvenile guinea pigs.

Authors:  Dawn Owen; Stephen G Matthews
Journal:  J Physiol       Date:  2006-10-26       Impact factor: 5.182

8.  Exposure to repeat doses of antenatal glucocorticoids is associated with altered cardiovascular status after birth.

Authors:  L F J Mildenhall; M R Battin; S M B Morton; C Bevan; C A Kuschel; J E Harding
Journal:  Arch Dis Child Fetal Neonatal Ed       Date:  2005-09-20       Impact factor: 5.747

9.  Normal neuropsychological development in children with congenital complete heart block who may or may not be exposed to high-dose dexamethasone in utero.

Authors:  A Brucato; M G Astori; R Cimaz; P Villa; M Li Destri; L Chimini; R Vaccari; M Muscarà; M Motta; A Tincani; F Neri; S Martinelli
Journal:  Ann Rheum Dis       Date:  2006-02-27       Impact factor: 19.103

10.  Prenatal glucocorticoid exposure alters hypothalamic-pituitary-adrenal function and blood pressure in mature male guinea pigs.

Authors:  Sonja Banjanin; Amita Kapoor; Stephen G Matthews
Journal:  J Physiol       Date:  2004-05-14       Impact factor: 5.182

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