Literature DB >> 10491743

Role of fatty acid beta-oxidation and calcium-independent phospholipase A2 in ischemic acute renal failure.

D Portilla1.   

Abstract

Membrane phospholipolysis during ischemic cell injury is accompanied by the activation of a novel calcium-independent phospholipase A2 in the proximal tubule. Long-chain fatty acid metabolic products produced by phospholipase A2 activation accumulate during ischemia as a result of the inhibition of fatty acid beta-oxidation on the mitochondria and peroxisomes. Altogether, lysophospholipids, long-chain acyl carnitines, and long-chain acyl coenzyme A inhibit proximal tubule Na+K(+)-ATPase. Metabolic regulation of the gene expression of fatty acid beta-oxidation enzymes during ischemic acute renal failure may represent a novel therapeutic maneuver to enhance the recovery of kidney function during ischemia.

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Year:  1999        PMID： 10491743     DOI： 10.1097/00041552-199907000-00012

Source DB:  PubMed          Journal:  Curr Opin Nephrol Hypertens        ISSN： 1062-4821            Impact factor:   2.894


  13 in total

1.  Early lipid changes in acute kidney injury using SWATH lipidomics coupled with MALDI tissue imaging.

Authors:  Sangeetha Rao; Kelly B Walters; Landon Wilson; Bo Chen; Subhashini Bolisetty; David Graves; Stephen Barnes; Anupam Agarwal; Janusz H Kabarowski
Journal:  Am J Physiol Renal Physiol       Date:  2016-02-24

2.  Serum metabolomic profiles from patients with acute kidney injury: a pilot study.

Authors:  Jinchun Sun; Melissa Shannon; Yosuke Ando; Laura K Schnackenberg; Nasim A Khan; Didier Portilla; Richard D Beger
Journal:  J Chromatogr B Analyt Technol Biomed Life Sci       Date:  2012-03-06       Impact factor: 3.205

Review 3.  Mitochondrial energetics in the kidney.

Authors:  Pallavi Bhargava; Rick G Schnellmann
Journal:  Nat Rev Nephrol       Date:  2017-08-14       Impact factor: 28.314

Review 4.  Pathophysiology of ischemic acute kidney injury.

Authors:  Asif A Sharfuddin; Bruce A Molitoris
Journal:  Nat Rev Nephrol       Date:  2011-03-01       Impact factor: 28.314

5.  Early loss of glutathione -s- transferase (GST) activity during diverse forms of acute renal tubular injury.

Authors:  Richard A Zager; Ali C M Johnson
Journal:  Physiol Rep       Date:  2022-06

6.  Complement-mediated activation of calcium-independent phospholipase A2γ: role of protein kinases and phosphorylation.

Authors:  Hanan Elimam; Joan Papillon; Tomoko Takano; Andrey V Cybulsky
Journal:  J Biol Chem       Date:  2012-12-20       Impact factor: 5.157

Review 7.  Peroxisomes and Kidney Injury.

Authors:  Radovan Vasko
Journal:  Antioxid Redox Signal       Date:  2016-04-22       Impact factor: 8.401

8.  Endothelial peroxisomal dysfunction and impaired pexophagy promotes oxidative damage in lipopolysaccharide-induced acute kidney injury.

Authors:  Radovan Vasko; Brian B Ratliff; Stefan Bohr; Ellen Nadel; Jun Chen; Sandhya Xavier; Praveen Chander; Michael S Goligorsky
Journal:  Antioxid Redox Signal       Date:  2013-01-04       Impact factor: 8.401

Review 9.  Alteration of Fatty Acid Oxidation in Tubular Epithelial Cells: From Acute Kidney Injury to Renal Fibrogenesis.

Authors:  Noémie Simon; Alexandre Hertig
Journal:  Front Med (Lausanne)       Date:  2015-08-05

Review 10.  Defective Mitochondrial Fatty Acid Oxidation and Lipotoxicity in Kidney Diseases.

Authors:  Hee-Seong Jang; Mi Ra Noh; Jinu Kim; Babu J Padanilam
Journal:  Front Med (Lausanne)       Date:  2020-03-12
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