Literature DB >> 10491599

Selective gene expression increases behavioral sensitivity to cocaine.

S E Hyman1.   

Abstract

Addictive drugs induce a truncated form of fosB in the striatum. A new study shows that mice engineered to mimic this expression pattern are abnormally sensitive to cocaine.

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Year:  1999        PMID: 10491599     DOI: 10.1038/13147

Source DB:  PubMed          Journal:  Nat Neurosci        ISSN: 1097-6256            Impact factor:   24.884


  1 in total

1.  Decreased expression of the transcription factor NURR1 in dopamine neurons of cocaine abusers.

Authors:  Michael J Bannon; Barb Pruetz; Amy B Manning-Bog; Christopher J Whitty; Sharon K Michelhaugh; Paola Sacchetti; James G Granneman; Deborah C Mash; Carl J Schmidt
Journal:  Proc Natl Acad Sci U S A       Date:  2002-04-16       Impact factor: 11.205

  1 in total

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