Literature DB >> 10491030

Evidence of absence of porcine endogenous retrovirus (PERV) infection in patients treated with a bioartificial liver support system.

Z Pitkin1, C Mullon.   

Abstract

Porcine endogenous retrovirus (PERV) genomes are present in all pig cells. In this retrospective study, we assessed PERV infectivity in 28 patients treated with an extracorporeal bioartificial liver (HepatAssist system) that includes a membrane device containing porcine hepatocytes. All patients tested negative for PERV using polymerase chain reaction analysis of peripheral blood mononuclear cells (PBMC) collected up to 5 years after treatment. In vitro results showed that the membrane decreased the risk of PERV transmission by a factor of 105, and porcine hepatocytes did not produce infectious PERV in co-cultures with human cell line 293. Our results do not support the presence of PERV infection in patients treated with this porcine hepatocyte-based bioartificial liver.

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Year:  1999        PMID： 10491030     DOI： 10.1046/j.1525-1594.1999.06444.x

Source DB:  PubMed          Journal:  Artif Organs        ISSN： 0160-564X            Impact factor:   3.094


  25 in total

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Authors:  M Soncini; A Scalvini; E Bignotti; C Pinoni; R Fouchier
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2.  Long-term safety from transmission of porcine endogenous retrovirus after pig-to-non-human primate corneal transplantation.

Authors:  Hyuk Jin Choi; Jiyeon Kim; Jae Young Kim; Hyun Ju Lee; Won Ryang Wee; Mee Kum Kim; Eung Soo Hwang
Journal:  Xenotransplantation       Date:  2017-05-14       Impact factor: 3.907

3.  Influence of chitosan nanofiber scaffold on porcine endogenous retroviral expression and infectivity in pig hepatocytes.

Authors:  Bing Han; Xiao-Lei Shi; Jiang-Qiang Xiao; Yue Zhang; Xue-Hui Chu; Jin-Yang Gu; Jia-Jun Tan; Zhong-Ze Gu; Yi-Tao Ding
Journal:  World J Gastroenterol       Date:  2011-06-14       Impact factor: 5.742

4.  Mapping full-length porcine endogenous retroviruses in a large white pig.

Authors:  C Herring; G Quinn; R Bower; N Parsons; N A Logan; A Brawley; K Elsome; A Whittam; X M Fernandez-Suarez; D Cunningham; D Onions; G Langford; L Scobie
Journal:  J Virol       Date:  2001-12       Impact factor: 5.103

5.  Prospective, randomized, multicenter, controlled trial of a bioartificial liver in treating acute liver failure.

Authors:  Achilles A Demetriou; Robert S Brown; Ronald W Busuttil; Jeffrey Fair; Brendan M McGuire; Philip Rosenthal; Jan Schulte Am Esch; Jan Lerut; Scott L Nyberg; Mauro Salizzoni; Elizabeth A Fagan; Bernard de Hemptinne; Christoph E Broelsch; Maurizio Muraca; Joan Manuel Salmeron; John M Rabkin; Herold J Metselaar; Daniel Pratt; Manuel De La Mata; Lawrence P McChesney; Gregory T Everson; Philip T Lavin; Anthony C Stevens; Zorina Pitkin; Barry A Solomon
Journal:  Ann Surg       Date:  2004-05       Impact factor: 12.969

6.  Absence of replication of porcine endogenous retrovirus and porcine lymphotropic herpesvirus type 1 with prolonged pig cell microchimerism after pig-to-baboon xenotransplantation.

Authors:  Nicolas C Issa; Robert A Wilkinson; Adam Griesemer; David K C Cooper; Kazuhiko Yamada; David H Sachs; Jay A Fishman
Journal:  J Virol       Date:  2008-10-01       Impact factor: 5.103

7.  Detection of PERV by polymerase chain reaction and its safety in bioartificial liver support system.

Authors:  Hai-Hui Wang; Ying-Jie Wang; Hong-Ling Liu; Jun Liu; Yan-Ping Huang; Hai-Tao Guo; Yu-Ming Wang
Journal:  World J Gastroenterol       Date:  2006-02-28       Impact factor: 5.742

8.  Reduced sensitivity to human serum inactivation of enveloped viruses produced by pig cells transgenic for human CD55 or deficient for the galactosyl-alpha(1-3) galactosyl epitope.

Authors:  Saema Magre; Yasuhiro Takeuchi; Gillian Langford; Andrew Richards; Clive Patience; Robin Weiss
Journal:  J Virol       Date:  2004-06       Impact factor: 5.103

9.  Porcine endogenous retrovirus transmission characteristics of galactose alpha1-3 galactose-deficient pig cells.

Authors:  Gary Quinn; James C Wood; David J J Ryan; Kristen M Suling; Kathleen M Moran; Donna L Kolber-Simonds; Julia L Greenstein; Henk-Jan Schuurman; Robert J Hawley; Clive Patience
Journal:  J Virol       Date:  2004-06       Impact factor: 5.103

10.  Genotyping of porcine endogenous retroviruses from a family of miniature swine.

Authors:  Gary Quinn; James Wood; Kristen Suling; Scott Arn; David H Sachs; Henk-Jan Schuurman; Clive Patience
Journal:  J Virol       Date:  2004-01       Impact factor: 5.103
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