Literature DB >> 10490534

High IL-18 (interferon-gamma inducing factor) concentration in a purine nucleoside phosphorylase deficient patient.

T Yamamoto1, Y Moriwaki, K Matsui, S Takahashi, H Tsutsui, T Yoshimoto, H Okamura, K Nakanishi, Y Kurosawa, S Yamaguchi, Y Sasaki, K Higashino.   

Abstract

The plasma concentration of IL-18 (interferon-gamma inducing factor) was severely increased in a 3 year old boy with purine nucleoside phosphorylase (PNP) deficiency. The presence and activity of IL-18 were confirmed by immunoblotting and bioassay, respectively. These results suggest that IL-18 may be abundantly produced and secreted into plasma by PNP deficient macrophages in PNP deficiency.

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Year:  1999        PMID： 10490534      PMCID： PMC1718032          DOI： 10.1136/adc.81.2.179

Source DB:  PubMed          Journal:  Arch Dis Child        ISSN： 0003-9888            Impact factor:   3.791


  4 in total

1.  Characterization of anti-human interleukin-18 (IL-18)/interferon-gamma-inducing factor (IGIF) monoclonal antibodies and their application in the measurement of human IL-18 by ELISA.

Authors:  M Taniguchi; K Nagaoka; T Kunikata; T Kayano; H Yamauchi; S Nakamura; M Ikeda; K Orita; M Kurimoto
Journal:  J Immunol Methods       Date:  1997-08-07       Impact factor: 2.303

Review 2.  Interleukin-18: a novel cytokine that augments both innate and acquired immunity.

Authors:  H Okamura; H Tsutsui; S Kashiwamura; T Yoshimoto; K Nakanishi
Journal:  Adv Immunol       Date:  1998       Impact factor: 3.543

3.  Mechanisms of deoxyguanosine lymphotoxicity. Human thymocytes, but not peripheral blood lymphocytes accumulate deoxy-GTP in conditions simulating purine nucleoside phosphorylase deficiency.

Authors:  L D Fairbanks; A Taddeo; J A Duley; H A Simmonds
Journal:  J Immunol       Date:  1990-01-15       Impact factor: 5.422

4.  Direct evidence of autosomal recessive inheritance of Arg24 to termination codon in purine nucleoside phosphorylase gene in a family with a severe combined immunodeficiency patient.

Authors:  Y Sasaki; M Iseki; S Yamaguchi; Y Kurosawa; T Yamamoto; Y Moriwaki; T Kenri; T Sasaki; R Yamashita
Journal:  Hum Genet       Date:  1998-07       Impact factor: 4.132
  4 in total
  1 in total

Review 1.  Pathogenic roles and diagnostic utility of interleukin-18 in autoinflammatory diseases.

Authors:  Masaki Shimizu; Syuji Takei; Masaaki Mori; Akihiro Yachie
Journal:  Front Immunol       Date:  2022-09-22       Impact factor: 8.786
  1 in total

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