| Literature DB >> 10488747 |
N Takashige1, T K Naruse, A Matsumori, M Hara, S Nagai, S Morimoto, S Hiramitsu, S Sasayama, H Inoko.
Abstract
Many studies have previously confirmed high TNFalpha (tumor necrosis factor-alpha) production in sarcoidosis, and have shown that TNFalpha plays an important role in granuloma formation. We investigated TNFA and TNFB (lymphotoxin-alpha) gene polymorphisms in 26 cardiac sarcoidosis patients of Japanese origin. These studies revealed a significant increase in the more uncommon TNFA2 allele in the patient group, suggesting that the TNFA gene controls the genetic susceptibility to cardiac sarcoidosis.Entities:
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Year: 1999 PMID： 10488747 DOI： 10.1034/j.1399-0039.1999.540211.x
Source DB: PubMed Journal: Tissue Antigens ISSN： 0001-2815