Hypoxysordarin, a new sordarin derivative from Hypoxylon croceum.

Hypoxysordarin (1), a new sordarin derivative, was isolated from the fermentation broth of the facultative marine Hypoxylon croceum together with a new gamma-lactone, hypoxylactone (2) and sordarin (3). The structures were determined by spectroscopic methods. Sordarin (3) has previously been isolated from the terrestrial Sordaria araneosa (Sordariaceae). Like the parent compound hypoxysordarin exhibits high antifungal activities due to a specific inhibition of protein biosynthesis.