Literature DB >> 10485731

Mild trimethylaminuria caused by common variants in FMO3 gene.

J Zschocke, D Kohlmueller, E Quak, T Meissner, G F Hoffmann, E Mayatepek.   

Abstract

Mild to transient trimethylaminuria is caused by common variants in the FMO3 gene leading to greatly reduced enzyme activity in vivo. FMO3 deficiency may have clinical relevance well beyond unpleasant body odour.

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Year:  1999        PMID： 10485731     DOI： 10.1016/s0140-6736(99)80019-1

Source DB:  PubMed          Journal:  Lancet        ISSN： 0140-6736            Impact factor:   79.321


  27 in total

1.  Biochemical and molecular studies in mild flavin monooxygenase 3 deficiency.

Authors:  J Zschocke; E Mayatepek
Journal:  J Inherit Metab Dis       Date:  2000-06       Impact factor: 4.982

2.  Clinical utility gene card for: trimethylaminuria.

Authors:  Elizabeth A Shephard; Eileen P Treacy; Ian R Phillips
Journal:  Eur J Hum Genet       Date:  2011-11-30       Impact factor: 4.246

3.  Relationships between flavin-containing mono-oxygenase 3 (FMO3) genotype and trimethylaminuria phenotype in a Japanese population.

Authors:  Makiko Shimizu; Charles K Allerston; Elizabeth A Shephard; Hiroshi Yamazaki; Ian R Phillips
Journal:  Br J Clin Pharmacol       Date:  2014-05       Impact factor: 4.335

4.  Molecular phylogeny, long-term evolution, and functional divergence of flavin-containing monooxygenases.

Authors:  Da Cheng Hao; Shi Lin Chen; Jun Mu; Pei Gen Xiao
Journal:  Genetica       Date:  2009-07-05       Impact factor: 1.082

5.  Riboflavin-responsive trimethylaminuria in a patient with homocystinuria on betaine therapy.

Authors:  Nigel J Manning; Elizabeth K Allen; Richard J Kirk; Mark J Sharrard; Edwin J Smith
Journal:  JIMD Rep       Date:  2011-11-20

Review 6.  Mammalian flavin-containing monooxygenases: structure/function, genetic polymorphisms and role in drug metabolism.

Authors:  Sharon K Krueger; David E Williams
Journal:  Pharmacol Ther       Date:  2005-06       Impact factor: 12.310

7.  Transient massive trimethylaminuria associated with food protein-induced enterocolitis syndrome.

Authors:  Natalie B Miller; Avraham Beigelman; Elizabeth Utterson; Marwan Shinawi
Journal:  JIMD Rep       Date:  2013-07-03

Review 8.  Where genotype is not predictive of phenotype: towards an understanding of the molecular basis of reduced penetrance in human inherited disease.

Authors:  David N Cooper; Michael Krawczak; Constantin Polychronakos; Chris Tyler-Smith; Hildegard Kehrer-Sawatzki
Journal:  Hum Genet       Date:  2013-07-03       Impact factor: 4.132

9.  Effects upon in-vivo nicotine metabolism reveal functional variation in FMO3 associated with cigarette consumption.

Authors:  A Joseph Bloom; Sharon E Murphy; Maribel Martinez; Linda B von Weymarn; Laura J Bierut; Alison Goate
Journal:  Pharmacogenet Genomics       Date:  2013-02       Impact factor: 2.089

10.  Novel variants of the human flavin-containing monooxygenase 3 (FMO3) gene associated with trimethylaminuria.

Authors:  Meike S Motika; Jun Zhang; Xueying Zheng; Kiersten Riedler; John R Cashman
Journal:  Mol Genet Metab       Date:  2009-02-27       Impact factor: 4.797
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