| Literature DB >> 10485656 |
S K Ye1, K Maki, T Kitamura, S Sunaga, K Akashi, J Domen, I L Weissman, T Honjo, K Ikuta.
Abstract
IL-7 receptor (IL-7R) plays critical roles in lymphocyte development by promoting survival and proliferation and by inducing V(D)J recombination in TCR and Ig loci. Here, we demonstrate that IL-7R-activated Stat5 binds to consensus motifs in the 5' regions of Jgamma segments and induces germline transcripts. We also show that a constitutively active form of Stat5 restores V-J recombination of TCRgamma genes and partially rescues T cell development from IL-7R(-/-) T cell precursors, especially in favor of gammadelta T cells. Therefore, this study reveals a potential role of Stat5 in T cell development and also implies that IL-7R may control the accessibility of the TCRgamma locus through Stat5-induced germline transcription.Entities:
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Year: 1999 PMID： 10485656 DOI： 10.1016/s1074-7613(00)80096-5
Source DB: PubMed Journal: Immunity ISSN： 1074-7613 Impact factor: 31.745