| Literature DB >> 10483380 |
Y Yang, K Kinoshita, K Koyama, K Takahashi, T Tai, Y Nunoura, K Watanabe.
Abstract
A novel experimental model of free radical-induced emesis for screening anti-emetic compounds from natural sources was established. 2,2'-Azobis(2-amidinopropane) dihydrochloride (AAPH) dissolved in liposome induced emesis in young chickens, and the emesis was prevented by antioxidants including N-(2-mercaptopropionyl)-glycine (MPG), alpha-tocopherol, and L-ascorbic acid. Tropiseton, a serotonin receptor antagonist, also prevented emesis induced by AAPH. Known anti-emetic drugs and anti-emetic principles from natural sources also showed significant retching inhibition in the experiment using this system.Entities:
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Year: 1999 PMID： 10483380 DOI： 10.1055/s-2006-960829
Source DB: PubMed Journal: Planta Med ISSN： 0032-0943 Impact factor: 3.352