Literature DB >> 10482645

Strong selective pressure for evolution of an Epstein-Barr virus LMP2B homologue in the rhesus lymphocryptovirus.

P Rivailler1, C Quink, F Wang.   

Abstract

Latent membrane protein 2B (LMP2B) is expressed during latent Epstein-Barr virus (EBV) infection, but little is known about its role. The goal of this study was to determine whether an LMP2B homologue is conserved in the rhesus monkey lymphocryptovirus (LCV). Both rhesus LCV LMP2A and LMP2B genes were cloned and sequenced. The rhesus LCV LMP2B gene is positionally conserved, and the EBNA-2 responsiveness and the bidirectional nature of the LMP1-LMP2B promoter have also been functionally conserved. However, this region of the genome encoding the LMP1, LMP1-LMP2B promoter, and LMP2B first exon demonstrates the most dramatic nucleotide sequence divergence between human and nonhuman LCV observed to date. Evolution of the rhesus LCV LMP2B promoter and transcript despite the dynamic nature of this genomic region reflects strong selective pressure for a yet-to-be-identified LMP2B function.

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Year:  1999        PMID： 10482645      PMCID： PMC112912          DOI： 10.1128/JVI.73.10.8867-8872.1999

Source DB:  PubMed          Journal:  J Virol        ISSN： 0022-538X            Impact factor:   5.103


  27 in total

1.  Inhibition of antigen presentation by the glycine/alanine repeat domain is not conserved in simian homologues of Epstein-Barr virus nuclear antigen 1.

Authors:  N W Blake; A Moghaddam; P Rao; A Kaur; R Glickman; Y G Cho; A Marchini; T Haigh; R P Johnson; A B Rickinson; F Wang
Journal:  J Virol       Date:  1999-09       Impact factor: 5.103

2.  The only domain which distinguishes Epstein-Barr virus latent membrane protein 2A (LMP2A) from LMP2B is dispensable for lymphocyte infection and growth transformation in vitro; LMP2A is therefore nonessential.

Authors:  R Longnecker; C L Miller; X Q Miao; A Marchini; E Kieff
Journal:  J Virol       Date:  1992-11       Impact factor: 5.103

3.  Two related Epstein-Barr virus membrane proteins are encoded by separate genes.

Authors:  J Sample; D Liebowitz; E Kieff
Journal:  J Virol       Date:  1989-02       Impact factor: 5.103

4.  Tyrosine 112 of latent membrane protein 2A is essential for protein tyrosine kinase loading and regulation of Epstein-Barr virus latency.

Authors:  S Fruehling; R Swart; K M Dolwick; E Kremmer; R Longnecker
Journal:  J Virol       Date:  1998-10       Impact factor: 5.103

5.  Activation of latent EBV via anti-IgG-triggered, second messenger pathways in the Burkitt's lymphoma cell line Akata.

Authors:  M Daibata; R E Humphreys; K Takada; T Sairenji
Journal:  J Immunol       Date:  1990-06-15       Impact factor: 5.422

6.  The terminal protein gene 2 of Epstein-Barr virus is transcribed from a bidirectional latent promoter region.

Authors:  G Laux; A Economou; P J Farrell
Journal:  J Gen Virol       Date:  1989-11       Impact factor: 3.891

7.  Transcriptional activation signals found in the Epstein-Barr virus (EBV) latency C promoter are conserved in the latency C promoter sequences from baboon and Rhesus monkey EBV-like lymphocryptoviruses (cercopithicine herpesviruses 12 and 15).

Authors:  E M Fuentes-Pananá; S Swaminathan; P D Ling
Journal:  J Virol       Date:  1999-01       Impact factor: 5.103

8.  Deletion of DNA encoding the first five transmembrane domains of Epstein-Barr virus latent membrane proteins 2A and 2B.

Authors:  R Longnecker; C L Miller; B Tomkinson; X Q Miao; E Kieff
Journal:  J Virol       Date:  1993-08       Impact factor: 5.103

9.  EBNA-2 of herpesvirus papio diverges significantly from the type A and type B EBNA-2 proteins of Epstein-Barr virus but retains an efficient transactivation domain with a conserved hydrophobic motif.

Authors:  P D Ling; J J Ryon; S D Hayward
Journal:  J Virol       Date:  1993-06       Impact factor: 5.103

10.  A spliced Epstein-Barr virus gene expressed in immortalized lymphocytes is created by circularization of the linear viral genome.

Authors:  G Laux; M Perricaudet; P J Farrell
Journal:  EMBO J       Date:  1988-03       Impact factor: 11.598
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  14 in total

1.  Structural, functional, and genetic comparisons of Epstein-Barr virus nuclear antigen 3A, 3B, and 3C homologues encoded by the rhesus lymphocryptovirus.

Authors:  H Jiang; Y G Cho; F Wang
Journal:  J Virol       Date:  2000-07       Impact factor: 5.103

2.  A role for SKIP in EBNA2 activation of CBF1-repressed promoters.

Authors:  S Zhou; M Fujimuro; J J Hsieh; L Chen; S D Hayward
Journal:  J Virol       Date:  2000-02       Impact factor: 5.103

3.  Transcriptional regulatory properties of Epstein-Barr virus nuclear antigen 3C are conserved in simian lymphocryptoviruses.

Authors:  Bo Zhao; Rozenn Dalbiès-Tran; Hua Jiang; Ingrid K Ruf; Jeffery T Sample; Fred Wang; Clare E Sample
Journal:  J Virol       Date:  2003-05       Impact factor: 5.103

4.  Minimal protein domain requirements for the intracellular localization and self-aggregation of Epstein-Barr virus latent membrane protein 2.

Authors:  Monica Jo Tomaszewski-Flick; David T Rowe
Journal:  Virus Genes       Date:  2007-06-13       Impact factor: 2.332

5.  An Epstein-Barr-related herpesvirus from marmoset lymphomas.

Authors:  Y Cho; J Ramer; P Rivailler; C Quink; R L Garber; D R Beier; F Wang
Journal:  Proc Natl Acad Sci U S A       Date:  2001-01-30       Impact factor: 11.205

6.  Complete genomic sequence of an Epstein-Barr virus-related herpesvirus naturally infecting a new world primate: a defining point in the evolution of oncogenic lymphocryptoviruses.

Authors:  Pierre Rivailler; Young-Gyu Cho; Fred Wang
Journal:  J Virol       Date:  2002-12       Impact factor: 5.103

Review 7.  Molecular evolution of the gamma-Herpesvirinae.

Authors:  D J McGeoch
Journal:  Philos Trans R Soc Lond B Biol Sci       Date:  2001-04-29       Impact factor: 6.237

8.  The CD8+ T-cell response to an Epstein-Barr virus-related gammaherpesvirus infecting rhesus macaques provides evidence for immune evasion by the EBNA-1 homologue.

Authors:  Mark H Fogg; Amitinder Kaur; Young-Gyu Cho; Fred Wang
Journal:  J Virol       Date:  2005-10       Impact factor: 5.103

Review 9.  Simian homologues of Epstein-Barr virus.

Authors:  F Wang; P Rivailler; P Rao; Y Cho
Journal:  Philos Trans R Soc Lond B Biol Sci       Date:  2001-04-29       Impact factor: 6.237

10.  Complete nucleotide sequence of the rhesus lymphocryptovirus: genetic validation for an Epstein-Barr virus animal model.

Authors:  Pierre Rivailler; Hua Jiang; Young-gyu Cho; Carol Quink; Fred Wang
Journal:  J Virol       Date:  2002-01       Impact factor: 5.103
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