Literature DB >> 10481969

The role of autosomal cell apoptosis regulator genes in human spermatogenesis.

W W Lin1, D J Lamb, L I Lipshultz, E D Kim.   

Abstract

Immunohistochemical analysis of the expression of the autosomal apoptosis regulator genes, BAX, bcl-2, p53, and cyclic-AMP responsive element modulator (CREM) in testis biopsies from infertile men demonstrated that BAX, bcl-2, and p53 immunoreactivity was absent irrespective of seminiferous tubule histology. In contrast, cell-specific CREM immunoreactivity in round spermatids, with complete absence of CREM in patient biopsies showing spermatocyte maturation arrest and Sertoli cell only, was evident, suggesting a possible role of autosomal genes in the regulation of apoptosis in human spermatogenesis regulation.

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Year:  1999        PMID： 10481969     DOI： 10.1023/a:1007137027543

Source DB:  PubMed          Journal:  Int Urol Nephrol        ISSN： 0301-1623            Impact factor:   2.370


  38 in total

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  1 in total

Review 1.  The CREM system in human spermatogenesis.

Authors:  A Peri; M Serio
Journal:  J Endocrinol Invest       Date:  2000-10       Impact factor: 4.256
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