Literature DB >> 10481215

Protection of the myocardium with sodium-hydrogen exchange inhibitors: A cardiac surgical perspective.

M L Myers1.   

Abstract

Strategies for myocardial protection in cardiac surgery are directed at the prevention of procedure-induced ischemia/reperfusion injury as well as metabolic resuscitation in acute ischemic syndromes. Postreperfusion myocardial dysfunction remains a significant clinical problem, most importantly in certain high-risk patient groups. The large body of experimental evidence demonstrating a significant role for sodium-hydrogen exchange activation in myocardial ischemia/reperfusion injury suggests that the ability to pharmacologically inhibit the exchanger presents a promising new approach to current myocardial preservation techniques.

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Year:  1999        PMID： 10481215     DOI： 10.1023/a:1008946715155

Source DB:  PubMed          Journal:  J Thromb Thrombolysis        ISSN： 0929-5305            Impact factor:   2.300


  48 in total

1.  Myocardial metabolism and ventricular function following cold potassium cardioplegia.

Authors:  S E Fremes; R D Weisel; D A Mickle; J Ivanov; M M Madonik; S J Seawright; S Houle; P R McLaughlin; R J Baird
Journal:  J Thorac Cardiovasc Surg       Date:  1985-04       Impact factor: 5.209

2.  The adrenergic response to surgery involving cardiopulmonary bypass, as measured by plasma and urinary catecholamine concentrations.

Authors:  I P Hine; W G Wood; R W Mainwaring-Burton; M J Butler; M H Irving; B Booker
Journal:  Br J Anaesth       Date:  1976-04       Impact factor: 9.166

3.  Polymorphonuclear leukocytes reduce cardiac function in vitro by release of H2O2.

Authors:  R Kraemer; B Seligmann; K M Mullane
Journal:  Am J Physiol       Date:  1990-06

4.  Na(+)-H+ exchange inhibition protects against mechanical, ultrastructural, and biochemical impairment induced by low concentrations of lysophosphatidylcholine in isolated rat hearts.

Authors:  A N Hoque; J V Haist; M Karmazyn
Journal:  Circ Res       Date:  1997-01       Impact factor: 17.367

5.  Beta-adrenergic stimulation reverses postischemic myocardial dysfunction without producing subsequent functional deterioration.

Authors:  R Bolli; W X Zhu; M L Myers; C J Hartley; R Roberts
Journal:  Am J Cardiol       Date:  1985-12-01       Impact factor: 2.778

6.  Na+/H+ exchange inhibition improves long-term myocardial preservation.

Authors:  Y I Kim; P Herijgers; S K Laycock; A Van Lommel; E Verbeken; W J Flameng
Journal:  Ann Thorac Surg       Date:  1998-08       Impact factor: 4.330

7.  New Na(+)-H+ exchange inhibitor HOE 694 improves postischemic function and high-energy phosphate resynthesis and reduces Ca2+ overload in isolated perfused rabbit heart.

Authors:  M Hendrikx; K Mubagwa; F Verdonck; K Overloop; P Van Hecke; F Vanstapel; A Van Lommel; E Verbeken; J Lauweryns; W Flameng
Journal:  Circulation       Date:  1994-06       Impact factor: 29.690

8.  Serial assessment of left ventricular performance following coronary artery bypass grafting. Early postoperative results with myocardial protection afforded by multidose hypothermic potassium crystalloid cardioplegia.

Authors:  A J Roberts; S M Spies; J H Sanders; J M Moran; C J Wilkinson; P R Lichtenthal; R L White; L L Michaelis
Journal:  J Thorac Cardiovasc Surg       Date:  1981-01       Impact factor: 5.209

9.  Mechanisms of reoxygenation-induced calcium overload in cardiac myocytes: dependence on pHi.

Authors:  N Matsuda; T Mori; H Nakamura; M Shigekawa
Journal:  J Surg Res       Date:  1995-12       Impact factor: 2.192

10.  Hydrogen peroxide changes in ischemic and reperfused heart. Cytochemistry and biochemical and X-ray microanalysis.

Authors:  J Slezak; N Tribulova; J Pristacova; B Uhrik; T Thomas; N Khaper; N Kaul; P K Singal
Journal:  Am J Pathol       Date:  1995-09       Impact factor: 4.307
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