Glucocorticoid Receptor beta: View II.

There is a clear role for mechanisms that modulate glucocorticoid receptor (GR) function. The non-steroid-binding GRbeta isoform has been proposed to play a role in this modulation but the published data are contradictory. The relative levels of this isoform appear to be low. Alternative mechanisms for the modulation of glucocorticoid action are described and contrasted with the proposed role for GRbeta.