Glucocorticoid Receptor beta: View I.

Since the human glucocorticoid receptor (GR) cDNA and gene sequences were reported, the existence of two highly homologous GR isoforms was predicted. These were the classic human ligand-binding GRalpha, and a slightly smaller protein, termed GRbeta. Although the mechanism of action of GRbeta has been studied extensively, the role of GRbeta in the modulation of glucocorticoid actions remains uncertain.