| Literature DB >> 10480375 |
S A Thomson1, S A Rasmussen, J Zhang, M R Wallace.
Abstract
Hereditary cylindromatosis (HC; MIM 132700) is an autosomal dominant condition characterized by benign skin appendage tumors most commonly on the scalp and face. Previously, the HC gene (CYLD1) was linked to chromosome 16q12-13, and tumors showed loss of heterozygosity (LOH), suggesting that CYLD1 is a tumor suppressor gene. Here we report a new multi-generation cylindromatosis family whose condition maps to that region, with 7/13 tumors showing LOH on 16q.Entities:
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Year: 1999 PMID： 10480375 DOI： 10.1007/s004399900077
Source DB: PubMed Journal: Hum Genet ISSN： 0340-6717 Impact factor: 4.132