Literature DB >> 10479314

DNA polymerase beta inhibitors from Sandoricum koetjape.

D A Sun1, S R Starck, E P Locke, S M Hecht.   

Abstract

Bioassay-guided fractionation of Sandoricum koetjape using an assay sensitive to DNA polymerase beta inhibition led to the isolation of three active compounds (1-3) having IC(50) values from 20 to 36 microM. Derivatives 5-14 were prepared from compounds 1 and 2; derivatives 11, 12, and 13 showed activity against DNA polymerase beta with IC(50) values ranging from 16 to 36 microM.

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Year:  1999        PMID： 10479314     DOI： 10.1021/np990104r

Source DB:  PubMed          Journal:  J Nat Prod        ISSN： 0163-3864            Impact factor:   4.050


  11 in total

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Journal:  Curr Mol Pharmacol       Date:  2012-01       Impact factor: 3.339

Review 2.  Molecular mechanism of adenomatous polyposis coli-induced blockade of base excision repair pathway in colorectal carcinogenesis.

Authors:  Satya Narayan; Ritika Sharma
Journal:  Life Sci       Date:  2015-09-01       Impact factor: 5.037

Review 3.  Hypersensitivity phenotypes associated with genetic and synthetic inhibitor-induced base excision repair deficiency.

Authors:  Julie K Horton; Samuel H Wilson
Journal:  DNA Repair (Amst)       Date:  2006-11-20

Review 4.  Medicinal chemistry and pharmacology of genus Tripterygium (Celastraceae).

Authors:  Anita M Brinker; Jun Ma; Peter E Lipsky; Ilya Raskin
Journal:  Phytochemistry       Date:  2007-01-23       Impact factor: 4.072

5.  Four limonoids from the seeds extract of Sandoricum koetjape.

Authors:  Miranti B Bumi; Leny Heliawaty; Elvira Hermawati; Yana M Syah
Journal:  J Nat Med       Date:  2019-04-10       Impact factor: 2.343

6.  Honokiol Inhibits DNA Polymerases β and λ and Increases Bleomycin Sensitivity of Human Cancer Cells.

Authors:  A S Prakasha Gowda; Zucai Suo; Thomas E Spratt
Journal:  Chem Res Toxicol       Date:  2017-01-19       Impact factor: 3.739

7.  DNA polymerases as potential therapeutic targets for cancers deficient in the DNA mismatch repair proteins MSH2 or MLH1.

Authors:  Sarah A Martin; Nuala McCabe; Michelle Mullarkey; Robert Cummins; Darren J Burgess; Yusaku Nakabeppu; Sugako Oka; Elaine Kay; Christopher J Lord; Alan Ashworth
Journal:  Cancer Cell       Date:  2010-03-16       Impact factor: 31.743

8.  Koetjapic acid chloro-form hemisolvate.

Authors:  Z D Nassar; A F A Aisha; A M S Abdul Majid; Chin Sing Yeap; Hoong-Kun Fun
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2010-05-08

9.  Antiangiogenic properties of Koetjapic acid, a natural triterpene isolated from Sandoricum koetjaoe Merr.

Authors:  Zeyad D Nassar; Abdalrahim Fa Aisha; Mohamed Bk Ahamed; Zhari Ismail; Khalid M Abu-Salah; Salman A Alrokayan; Amin Malik Shah Abdul Majid
Journal:  Cancer Cell Int       Date:  2011-04-27       Impact factor: 5.722

Review 10.  DNA Polymerases λ and β: The Double-Edged Swords of DNA Repair.

Authors:  Elisa Mentegari; Miroslava Kissova; Laura Bavagnoli; Giovanni Maga; Emmanuele Crespan
Journal:  Genes (Basel)       Date:  2016-08-31       Impact factor: 4.096
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