Literature DB >> 10479126

Longitudinal human immunodeficiency virus type 1 load in the italian seroconversion study: correlates and temporal trends of virus load.

C M Lyles1, M Dorrucci, D Vlahov, P Pezzotti, G Angarano, A Sinicco, F Alberici, T M Alcorn, S Vella, G Rezza.   

Abstract

A prospective study of 149 human immunodeficiency virus type 1 (HIV-1) seroconverters was conducted to describe trends and correlates of HIV-1 load after seroconversion and over time. HIV-1 load was quantified from frozen sera by reverse transcriptase-polymerase chain reaction. High early virus load was associated with lower CD4 cell counts and male sex but not with age at seroconversion or injection drug use. Early virus load predicted progression to clinical AIDS and AIDS/<200 CD4 cells/microL. Virus load exhibited a decline of 52% by 18 months after seroconversion then increased 23% annually (95% confidence interval, 13%-33%). Men and those developing AIDS during follow-up had higher virus loads over the course of disease. Persons who developed AIDS had a steeper virus load slope than those who were AIDS-free (P=.01). In long-term follow-up, virus load exhibited a gradual and sustained increase over time. Virus load and annual increase are strong predictors of disease progression.

Entities:  

Mesh：

Substances：

Year:  1999        PMID： 10479126     DOI： 10.1086/314980

Source DB:  PubMed          Journal:  J Infect Dis        ISSN： 0022-1899            Impact factor:   5.226


  18 in total

1.  Dynamics of viremia in primary HIV-1 infection in Africans: insights from analyses of host and viral correlates.

Authors:  Heather A Prentice; Matthew A Price; Travis R Porter; Emmanuel Cormier; Michael J Mugavero; Anatoli Kamali; Etienne Karita; Shabir Lakhi; Eduard J Sanders; Omu Anzala; Pauli N Amornkul; Susan Allen; Eric Hunter; Richard A Kaslow; Jill Gilmour; Jianming Tang
Journal:  Virology       Date:  2013-12-12       Impact factor: 3.616

Review 2.  Immune modulation by estrogens: role in CNS HIV-1 infection.

Authors:  Melinda E Wilson; Filomena O Dimayuga; Janelle L Reed; Thomas E Curry; Carol F Anderson; Avindra Nath; Annadora J Bruce-Keller
Journal:  Endocrine       Date:  2006-04       Impact factor: 3.633

3.  Efficient use of longitudinal CD4 counts and viral load measures in survival analysis.

Authors:  S E Holte; T W Randolph; J Ding; J Tien; R S McClelland; J M Baeten; J Overbaugh
Journal:  Stat Med       Date:  2012-03-13       Impact factor: 2.373

4.  Sex differences in the Toll-like receptor-mediated response of plasmacytoid dendritic cells to HIV-1.

Authors:  Angela Meier; J Judy Chang; Ellen S Chan; Richard B Pollard; Harlyn K Sidhu; Smita Kulkarni; Tom Fang Wen; Robert J Lindsay; Liliana Orellana; Donna Mildvan; Suzane Bazner; Hendrik Streeck; Galit Alter; Jeffrey D Lifson; Mary Carrington; Ronald J Bosch; Gregory K Robbins; Marcus Altfeld
Journal:  Nat Med       Date:  2009-07-13       Impact factor: 53.440

Review 5.  The role of antigenic stimulation and cytotoxic T cell activity in regulating the long-term immunopathogenesis of HIV: mechanisms and clinical implications.

Authors:  C Fraser; N M Ferguson; F de Wolf; R M Anderson
Journal:  Proc Biol Sci       Date:  2001-10-22       Impact factor: 5.349

6.  Better Viral Control despite Higher CD4+ T Cell Activation during Acute HIV-1 Infection in Zambian Women Is Linked to the Sex Hormone Estradiol.

Authors:  Elina El-Badry; Gladys Macharia; Daniel Claiborne; Kelsie Brooks; Darío A Dilernia; Paul Goepfert; William Kilembe; Susan Allen; Jill Gilmour; Eric Hunter
Journal:  J Virol       Date:  2020-07-30       Impact factor: 5.103

7.  Kaposi sarcoma incidence and survival among HIV-infected homosexual men after HIV seroconversion.

Authors:  Sara Lodi; Marguerite Guiguet; Dominique Costagliola; Martin Fisher; Andrea de Luca; Kholoud Porter
Journal:  J Natl Cancer Inst       Date:  2010-05-04       Impact factor: 13.506

8.  HIV-associated nephropathy and end-stage renal disease in children in the United States.

Authors:  Tejinder S Ahuja; Kevin C Abbott; Laura Pack; Yong-Fang Kuo
Journal:  Pediatr Nephrol       Date:  2004-05-13       Impact factor: 3.714

9.  Sex-Based Differences in Human Immunodeficiency Virus Type 1 Reservoir Activity and Residual Immune Activation.

Authors:  Eileen P Scully; Monica Gandhi; Rowena Johnston; Rebecca Hoh; Ainsley Lockhart; Curtis Dobrowolski; Amélie Pagliuzza; Jeffrey M Milush; Christopher A Baker; Valerie Girling; Arlvin Ellefson; Robert Gorelick; Jeffrey Lifson; Marcus Altfeld; Galit Alter; Marcelle Cedars; Ajantha Solomon; Sharon R Lewin; Jonathan Karn; Nicolas Chomont; Peter Bacchetti; Steven G Deeks
Journal:  J Infect Dis       Date:  2019-03-15       Impact factor: 5.226

10.  Human immunodeficiency virus-specific CD8+ T-cell activity is detectable from birth in the majority of in utero-infected infants.

Authors:  Christina F Thobakgale; Dhanwanthie Ramduth; Sharon Reddy; Nompumelelo Mkhwanazi; Chantal de Pierres; Eshia Moodley; Wendy Mphatswe; Natasha Blanckenberg; Ayanda Cengimbo; Andrew Prendergast; Gareth Tudor-Williams; Krista Dong; Prakash Jeena; Gupreet Kindra; Raziya Bobat; Hoosen Coovadia; Photini Kiepiela; Bruce D Walker; Philip J R Goulder
Journal:  J Virol       Date:  2007-09-19       Impact factor: 5.103
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.