| Literature DB >> 10478801 |
J A Ulibarri1, P E Mozdziak, E Schultz, C Cook, T M Best.
Abstract
Nitric oxide (NO) is an inter- and intracellular messenger involved in a variety of physiologic and pathophysiologic conditions. The effect of two NO donors, sodium nitroprusside (SNP) and S-nitroso-N-acetylpenicillamine (SNAP) and their effect on myoblast proliferation was examined. Both donors stimulated an increase in myoblast cell number over a range (1-10 microM) of donor concentrations. However, 50 microM SNAP inhibited myoblast proliferation. Cell numbers from cultures treated with degraded 10 microM SNAP were equivalent to the control. Therefore, it appears NO can stimulate as well as inhibit myoblast proliferation.Entities:
Keywords: NASA Discipline Musculoskeletal; Non-NASA Center
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Year: 1999 PMID: 10478801 DOI: 10.1007/s11626-999-0029-1
Source DB: PubMed Journal: In Vitro Cell Dev Biol Anim ISSN: 1071-2690 Impact factor: 2.416