Study of the complexation behaviour of gliclazide with partially methylated beta-cyclodextrin in solution and solid state.

The complexation of Gliclazide (GL) with a partially methylated beta-cyclodextrin was studied. Phase-solubility and (1)H NMR spectroscopy were employed to investigate the complexation behaviour in solution and to demonstrate the complexation in liquid medium with the participation of both azabicyclooctyl and tolyl moieties of GL in the inclusion process. Solid systems prepared by kneading, co-grinding and spray drying have also been checked, using DSC and HSM, for assessing the formation of the inclusion compound. Experimental evidence of the complexation between drug and cyclodextrin was reported for the co-ground and spray-dried systems.