Literature DB >> 10476871

P2-achiral, P'-extended alpha-ketoamide inhibitors of calpain I.

S Chatterjee1, D Dunn, M Tao, G Wells, Z Q Gu, R Bihovsky, M A Ator, R Siman, J P Mallamo.   

Abstract

A series of potent P2-achiral, P'-extended alpha-ketoamide inhibitors of calpain I is described.

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Year:  1999        PMID： 10476871     DOI： 10.1016/s0960-894x(99)00392-3

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  3 in total

1.  Peptidyl alpha-ketoamides with nucleobases, methylpiperazine, and dimethylaminoalkyl substituents as calpain inhibitors.

Authors:  Asli Ovat; Zhao Zhao Li; Christina Y Hampton; Seneshaw A Asress; Facundo M Fernández; Jonathan D Glass; James C Powers
Journal:  J Med Chem       Date:  2010-09-09       Impact factor: 7.446

2.  Cocrystal structures of primed side-extending alpha-ketoamide inhibitors reveal novel calpain-inhibitor aromatic interactions.

Authors:  Jin Qian; Dominic Cuerrier; Peter L Davies; Zhaozhao Li; James C Powers; Robert L Campbell
Journal:  J Med Chem       Date:  2008-08-15       Impact factor: 7.446

3.  General and Modular Strategy for Designing Potent, Selective, and Pharmacologically Compliant Inhibitors of Rhomboid Proteases.

Authors:  Anežka Tichá; Stancho Stanchev; Kutti R Vinothkumar; David C Mikles; Petr Pachl; Jakub Began; Jan Škerle; Kateřina Švehlová; Minh T N Nguyen; Steven H L Verhelst; Darren C Johnson; Daniel A Bachovchin; Martin Lepšík; Pavel Majer; Kvido Strisovsky
Journal:  Cell Chem Biol       Date:  2017-10-26       Impact factor: 8.116
  3 in total

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